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, Volume 41, Supplement 1, pp C80–C81 | Cite as

Pituitary-adrenocortical responsiveness to histaminergic stimulation during social stress of crowding in rats

  • A. Gądek-Michalska
  • J. Borycz
  • J. Bugajski
Histamine and the Central Nervous System

Abstract

Social stress of crowding for 3, 7, 14 and 21 days drastically reduces the serum corticosterone response to intracerebroventricular administration of dimaprit, a histamine H2-receptor agonist, moderately diminishes the response to pyridylethylamine, an H1-receptor agonist, and does not change significantly the corticosterone response to histamine.

These results suggest that social stress of crowding considerably desensitizes central histamine H2-receptors involved in stimulation of the hypothalamic-pituitary-adrenal axis.

Keywords

Histamine Corticosterone Social Stress Serum Corticosterone Intracerebroventricular Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Birkhäuser Verlag 1994

Authors and Affiliations

  • A. Gądek-Michalska
    • 1
  • J. Borycz
    • 1
  • J. Bugajski
    • 1
  1. 1.Institute of PharmacologyPolish Academy of SciencesKrakówPoland

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