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Acute toxicity of folic acid in mice

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  • Pharmacology, Toxicology
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Summary

The toxicity of folic acid (PGA) was studied in different inbred strains of mice. LD50 values of PGA by the i.p. route showed a unique toxicity pattern. In some strains, convulsions, ataxia and weakness were observed. Histopathological study in strains S/RVCri, BDF1, DBA/2 and DBA/2fNCri showed acute renal tubular necrosis.

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Authors and Affiliations

  1. Chemotherapy Division, Cancer Research Institute, Tata Memorial Centre, Parel, 400012, Bombay, India

    M. Parchure, R. Y. Ambaye, V. S. Lalitha & S. V. Gokhale

  2. Cell and Developmental Pathology Division, Cancer Research Institute, Tata Memorial Centre, Parel, 400012, Bombay, India

    M. Parchure, R. Y. Ambaye, V. S. Lalitha & S. V. Gokhale

Authors
  1. M. Parchure
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  2. R. Y. Ambaye
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  3. V. S. Lalitha
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  4. S. V. Gokhale
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Additional information

Acknowledgment. The authors thank Ms N. Hasgekar for her technical assistance

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Parchure, M., Ambaye, R.Y., Lalitha, V.S. et al. Acute toxicity of folic acid in mice. Experientia 41, 72–73 (1985). https://doi.org/10.1007/BF02005881

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