Increase in pituitary melanocyte-stimulating hormone activity of genetically obese (ob/ob) mice
- 6 Downloads
Melanocyte-stimulating hormone (MSH) activity was measured in the pituitaries of genetically obese and lean control mice using the frog skin bioassay. Obese mice pituitaries demonstrated very significantly elevated levels of biologically active MSH when compared to their lean littermates. These results support the hypothesis that the elevated levels of pituitary hormones found in obese mice possess true biological activity.
KeywordsBiological Activity Elevated Level Control Mouse Hormone Activity Pituitary Hormone
- 4.S. Beevor, A. Beloff-Chain, A. Donaldson and J. A. Edwardson, J. Physiol.275, 55P (1977).Google Scholar