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Experientia

, Volume 36, Issue 1, pp 97–98 | Cite as

Human neuropharmacological findings with oxapadol (MD 720111), a new non-narcotic analgesic

  • F. Boureau
  • B. Laquais
  • M. Vadrot
  • J. -C. Willer
Specialia

Summary

The effects of oxapadol, a new non-narcotic analgesic, were tested in man using the electrically-induced nociceptive flexion reflex in the flexor muscles of the lower limb as an index of pain. The drug caused a significant increase in the threshold of the reflex whereas no change was noted with placebo.

Keywords

Placebo Flexor Muscle Nociceptive Flexion 

References

  1. 2.
    Oxapadol: 4,5-dihydro-1-phenyl-1,4-epoxy-1H, 3H-[1,4]oxazepino [4,3-a]benzimidazole. C. Fauran, J. Eberlé, M. Turin, G. Raynaud and C. Gouret, U.S. Patent 3591.968, April 20, 1976.Google Scholar
  2. 3.
    G. Mocquet, A. Coston and M. Jalfre, Experientia, in press.Google Scholar
  3. 4.
    J.C. Willer and N. Bathien, Electromyogr. Clin. Neurophysiol.15, 127 (1975).PubMedGoogle Scholar
  4. 5.
    J.C. Willer, Pain3, 69 (1977).CrossRefGoogle Scholar
  5. 6.
    J.C. Willer, Physiol. Behav.15, 411 (1975).CrossRefGoogle Scholar
  6. 7.
    F. Boureau, J.C. Willer and C. Dauthier, J. Neuropharmac.17, 565 (1978).CrossRefGoogle Scholar
  7. 8.
    S. Wallenstein and A.C. Fischer, Biometrics33, 261 (1977).CrossRefGoogle Scholar
  8. 9.
    J.C. Willer and N. Bathien, Pain3, 111 (1977).CrossRefGoogle Scholar
  9. 10.
    J.C. Willer, N. Bathien and A. Hugelin, in: Advance in Pain Research and Therapy, vol. 1. p. 131. Ed. J.J. Bonica and D. Albe-Fessard. Raven Press, New York 1976.Google Scholar
  10. 11.
    A. Lundberg, in: Progress in Brain Research, Physiology of Spinal Neurons, vol. 12, p. 135. Ed. J.C. Eccles and J.P. Schade, Elsevier, Amsterdam 1964.Google Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • F. Boureau
    • 1
    • 2
  • B. Laquais
    • 1
    • 2
  • M. Vadrot
    • 1
    • 2
  • J. -C. Willer
    • 1
    • 2
  1. 1.Laboratoire de Neurophysiologie CliniqueHôpital Saint-AntoineParisFrance
  2. 2.Unité de Recherche CliniqueCentre de Recherche DelalandeRueil-MalmaisonFrance

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