Advertisement

Pharmaceutisch Weekblad

, Volume 6, Issue 5, pp 203–208 | Cite as

Pulsed proton NMR and solid-liquid fat ratio determinations in suppository vehicles and aminophylline suppositories

  • C. J. De Blaey
  • F. A. Varkevisser
  • A. Kalk
Original Articles
  • 31 Downloads

Abstract

The physical state, melting behaviour and release rate of aminophylline suppositories were studied during storage. The fraction of non-crystallized fat, assessed by pulse NMR, varies between different vehicles. At room temperature several vehicles do not seem to be completely crystalline. Aging, as observed in prolonged melting time and a reduced release rate, is not expressed in a drastic reduction of the fraction of non-crystallized fat, as observed by NMR. On the contrary the mobility of the protons in the non-crystallized state is likely to offer a more promising tool to monitor aging.

Keywords

Public Health Internal Medicine Physical State Release Rate Promising Tool 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    De Blaey CJ, Polderman J. Rationales in the design of rectal and vaginal delivery forms of drugs. In: Ariëns EJ, ed. Drug Design, vol. IX. London-New York: Academic Press, 1980:237.Google Scholar
  2. 2.
    Brower JF, Juenge EC, Page DP, Dow ML. Decomposition of aminophylline in suppository formulations. J Pharm Sci 1980;69:942–5.PubMedGoogle Scholar
  3. 3.
    Official and Tentative methods of the American Oil Chemists Society, 3rd ed. Champaign: AOCS, 1973.Google Scholar
  4. 4.
    Van Putte KPAM, Van den Enden J. Pulse NMR as a quick method for the determination of the solid fat content in partially crystallized fats. J Phys E Sci Instr 1973;6:910–2.CrossRefGoogle Scholar
  5. 5.
    Van Putte KPAM, Van den Enden J. Fully automated determination of solid fat content by pulsed NMR. J Am Oil Chemists' Soc 1974;51:316–20.Google Scholar
  6. 6.
    Van Boekel MAJS. Estimation of Solid-liquid Ratios in Bulk Fats and emulsions by Pulsed Nuclear Magnetic Resonance. J Am Oil Chemists' Soc 1981, 58:767–72.Google Scholar
  7. 7.
    Mills BL, Van de Voort FR. Comparison of the direct and indirect wide-line nuclear magnetic resonance methods for determining solid fat content. J Am Oil Chemists' Soc 1981;58:776–8.Google Scholar
  8. 8.
    Farrar TC, Becker ED. Pulse and Fourier transform NMR. London-New York: Academic Press, 1971.Google Scholar
  9. 9.
    De Blaey CJ, Rutten-Kingma JJ. Biopharmaceutics of aminophylline suppositories I. Introduction andin vitro melting behaviour. Pharm Acta Helv 1976;51:186–92.PubMedGoogle Scholar
  10. 10.
    De Blaey CJ, Rutten-Kingma JJ. Biopharmaceutics of aminophylline suppositories. II.In vitro release rate during storage. Pharm Acta Helv 1977;52:11–4.PubMedGoogle Scholar
  11. 11.
    Lyerla JR. High resoltion nuclear magnetic resonance spectroscopy. In: Rava RR, ed. Polymers. (Marton L, Marton C, eds. Methods of Experimental Physics. Vol. 16.) London-New York: Academic Press, 1980.Google Scholar
  12. 12.
    Andrew ER. Molecular motions in certain solid hydrocarbons. J Chem Phys 1950;18:607–18.CrossRefGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • C. J. De Blaey
    • 1
  • F. A. Varkevisser
    • 2
  • A. Kalk
    • 3
  1. 1.Royal Dutch Association for Advancement of PharmacyJL The HagueThe Netherlands
  2. 2.Faculty of PharmacyUniversity of LeidenRA LeidenThe Netherlands
  3. 3.Faculty of PharmacyUniversity of UtrechtGH UtrechtThe Netherlands

Personalised recommendations