Pulsed proton NMR and solid-liquid fat ratio determinations in suppository vehicles and aminophylline suppositories
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The physical state, melting behaviour and release rate of aminophylline suppositories were studied during storage. The fraction of non-crystallized fat, assessed by pulse NMR, varies between different vehicles. At room temperature several vehicles do not seem to be completely crystalline. Aging, as observed in prolonged melting time and a reduced release rate, is not expressed in a drastic reduction of the fraction of non-crystallized fat, as observed by NMR. On the contrary the mobility of the protons in the non-crystallized state is likely to offer a more promising tool to monitor aging.
KeywordsPublic Health Internal Medicine Physical State Release Rate Promising Tool
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- 1.De Blaey CJ, Polderman J. Rationales in the design of rectal and vaginal delivery forms of drugs. In: Ariëns EJ, ed. Drug Design, vol. IX. London-New York: Academic Press, 1980:237.Google Scholar
- 3.Official and Tentative methods of the American Oil Chemists Society, 3rd ed. Champaign: AOCS, 1973.Google Scholar
- 5.Van Putte KPAM, Van den Enden J. Fully automated determination of solid fat content by pulsed NMR. J Am Oil Chemists' Soc 1974;51:316–20.Google Scholar
- 6.Van Boekel MAJS. Estimation of Solid-liquid Ratios in Bulk Fats and emulsions by Pulsed Nuclear Magnetic Resonance. J Am Oil Chemists' Soc 1981, 58:767–72.Google Scholar
- 7.Mills BL, Van de Voort FR. Comparison of the direct and indirect wide-line nuclear magnetic resonance methods for determining solid fat content. J Am Oil Chemists' Soc 1981;58:776–8.Google Scholar
- 8.Farrar TC, Becker ED. Pulse and Fourier transform NMR. London-New York: Academic Press, 1971.Google Scholar
- 11.Lyerla JR. High resoltion nuclear magnetic resonance spectroscopy. In: Rava RR, ed. Polymers. (Marton L, Marton C, eds. Methods of Experimental Physics. Vol. 16.) London-New York: Academic Press, 1980.Google Scholar