European Journal of Pediatrics

, Volume 149, Issue 2, pp 76–79 | Cite as

Somatomedin-binding proteins: What role do they play in the growth process?

  • S. Cianfarani
  • J. M. P. Holly


The insulin-like growth factors (IGF-I and IGF-II) circulate bound to specific proteins. Two classes of binding proteins have been relatively well characterized differing in size, immunological activity, and physiological function. This review summarizes the more recent data on IGF-binding proteins, focusing on their possible clinical implications.

Key words

Insulin-like growth factor binding proteins Insulin-like growth factors Growth 



growth hormone


insulin-like growth factor binding protein

IGF (I and II)

insulin-like growth factor (I and II)


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • S. Cianfarani
    • 1
  • J. M. P. Holly
    • 2
  1. 1.Department of Paediatrics“Tor Vergata” University Medical School, II University of Rome, Dip. San. Biol. Cell.RomaItaly
  2. 2.Department of Chemical EndocrinologySt. Bartholomew's HospitalLondonUK

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