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, Volume 34, Issue 1–2, pp 165–168 | Cite as

Corticosteroids and immunosuppressive agents in rabbit heterolamellar corneal transplant model

  • E. Ohia
  • P. Kulkarni
Autoimmunity

Abstract

Bovine cornea (epithelium and stroma) was transplanted on to the rabbit cornea from which the epithelium and stroma had been removed. Conjuntival hyperemia and edema occurred from day 1–5 post-operation, followed by neovascularization and graft rejection within 7–10 days. Topical dexamethasone (0.1%) and prednisolone (1%) t.i.d. inhibited post-surgical hyperemia, edema, delayed hypersensitivity and neovascularization. These agents and the immunosuppressants (cyclosporin A and rapamycin) inhibited graft rejection observed up to 20 days. After cessation of treatment on the 2oth day, grafts remained viable up to 35 days with dexamethasone, 10 days with prednisolone and rapamycin, and 5 days with cyclosporin A.

Keywords

Corticosteroid Dexamethasone Cyclosporin Prednisolone Rapamycin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • E. Ohia
    • 1
  • P. Kulkarni
    • 1
  1. 1.Department of Ophthalmology and Visual SciencesKentucky Lions Eye Research Institute University of LouisvilleLouisvilleUSA

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