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, Volume 34, Issue 1–2, pp 161–164 | Cite as

Inhibitory effects of the anti-rat T-cell receptor (TCR) monoclonal antibody (MAb) R73 on various experimental autoimmune diseases

  • H. U. Schorlemmer
  • E. J. Kanzy
  • R. Kurrle
  • F. R. Seiler
Autoimmunity

Abstract

The anti-ratα/β-TCR, MAb-R73 has been investigated as to its disease modifying activity on adjuvant arthritis (AA), on experimental allergic encephalomyelitis (EAE) and on a local graft versus host (GvH) reaction (popliteal lymph nodes=PLN) in Lewis or Brown-Norway rats. R73 was able to prevent the onset of the AA and even if therapy started after the establishment of AA the MAb was still able to reduce the degree of chronic inflammation and arrest its progress. Intraveneous MAb-R73 application also reduced the signs of EAE and prevented mortality. This was even seen when the substance was given after the outbreak of the clinical symptoms or when the F(ab)2 fragment of this MAb was used. Also in the model of local GvH reaction R73 acted therapeutically and lowered the PLN weights.

Keywords

Lymph Node Arthritis Monoclonal Antibody Autoimmune Disease Clinical Symptom 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [1]
    R. Kurrle, K. H. Enssle and F. R. Seiler,Monoclonal antibodies directed to the leukocyte differentiation antigens for therapeutic use. Behring Inst. Mitt.82, 154–173 (1988)PubMedGoogle Scholar
  2. [2]
    H. U. Schorlemmer, E. J. Kanzy, R. Kurrle and F. R. Seiler,Prolongation of allogeneic transplantation skin grafts by the anti-rat-TCR monoclonal antibody R73. Immunobiology181, 236–237 (1990).Google Scholar
  3. [3]
    H. U. Schorlemmer, E. J. Kanzy, R. Kurrle and F. R. Seiler,Inhibition of various experimental autoimmune diseases by the anti-rat-TCR monoclonal antibody R73. Immunobiology181, 222–223 (1990).Google Scholar
  4. [4]
    T. Hünig, H. J. Wallny, J. K. Hartley, A. Lawetzky and G. J. Tiefenthaler,A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. J. Exp. Med.169, 73–86 (1989).CrossRefPubMedGoogle Scholar
  5. [5]
    W. L. Ford, W. Burr and G. Simonsen,A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells. Transplantation10, 258–266 (1970).PubMedGoogle Scholar
  6. [6]
    R. J. Perper, B. Alvarez, C. Colombo and H. Schröder,The use of a standardized adjuvant arthritis assay to differentiate between antiinflammatory and immunosuppressive agents. Proc. Soc. Exp. Biol. Med.137, 506–514 (1971).Google Scholar

Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • H. U. Schorlemmer
    • 1
  • E. J. Kanzy
    • 1
  • R. Kurrle
    • 1
  • F. R. Seiler
    • 1
  1. 1.Research Laboratories of Behringwerke AGMarburg/LahnFRG

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