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, Volume 33, Issue 1–2, pp 104–107 | Cite as

Neurofibrillary tangles and histamine-containing neurons in Alzheimer hypothalamus

  • M. S. Airaksinen
  • K. Reinikainen
  • P. Riekkinen
  • P. Panula
Histamine and the Nervous System

Abstract

The location of histamine-immunoreactive (IR) cell bodies in normal aged human brain and in cases of Alzheimer's disease (AD) were compared to the distribution of neurofibrillary tangles (NFT). Cryostat sections were fixed with carbodiimide and processed for histamine-immunohistochemistry using the PAP technique. NFT were visualized in the same sections using thioflavin. Histamine-IR cell bodies in human brain were concentrated in the tuberomammillary (TM) nucleus that embodied a major part of the hypothalamus. Although located in similar large profiles and mainly concentrated in the TM area, the numerous hypothalamic NFT in AD were seldom found within the histamine-IR neurons.

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References

  1. [1]
    P. Panula, M. S. Airaksinen, U. Pirvola and E. Kotilainen,Histamine-containing neuronal system in human brain. Neuroscience34, 129–132 (1990).Google Scholar
  2. [2]
    C. B. Saper and D. C. German,Hypothalamic pathology in Alzheimer's disease. Neurosci. Lett.74, 364–370 (1987).PubMedGoogle Scholar
  3. [3]
    J. A. Hardy, D. M. A. Mann, P. Wester and B. Winblad,An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease. Neurobiol. Aging7, 489–502 (1986).PubMedGoogle Scholar
  4. [4]
    P. Panula and M. S. Airaksinen,The histaminergic neuronal system as revealed with antisera against histamine. InHistaminergic neurons, their functions and morphology, (Ed. T. Watanabe and H. Wada), CRC-Press, Boca (1990, in press).Google Scholar
  5. [5]
    R. Diepen,Der Hypothalamus. InHandbuch der Mikroskopischen Anatomie des Menschen, VII Teil (Ed. W. V. Mollendorf), pp. 1–525, Springer, Verlag, Berlin 1962.Google Scholar
  6. [6]
    R. Cacabelos, A. Yamatodani, H. Niigawa, S. Hariguchi, K. Tada, T. Nishimura, H. Wada, L. Brandes and J. Pearson.Brain histamine in Alzheimer's disease. Meth. Find. Exp. Clin. Pharmacol.11, 353–360 (1989).Google Scholar
  7. [7]
    I. M. Mazurkiewicz-Kwilecki and S. Nsonwah.Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients. Can. J. Physiol. Pharmacol.67, 75–78 (1988).Google Scholar

Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • M. S. Airaksinen
    • 1
  • K. Reinikainen
    • 2
  • P. Riekkinen
    • 2
  • P. Panula
    • 1
  1. 1.Department of AnatomyUniversity of HelsinkiHelsinkiFinland
  2. 2.Department of NeurologyUniversity of KuopioKuopioFinland

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