, Volume 32, Issue 5, pp 645–647 | Cite as

The effects of tryptophol on immune responses and its implications toward trypanosome-induced immunosuppression

  • S. B. Ackerman
  • J. R. Seed


Daily administrations of tryptophol to laboratory rodents resulted in significantly depressed antibody production to heterologous red blood cell challenge, but did not alter cellular-mediated responses to oxazalone. These results suggest that trypanosome-produced tryptophol may account for the immunodepression observed during trypanosomiasis.


Immune Response Blood Cell Antibody Production Daily Administration Trypanosomiasis 
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  1. 3.
    L. G. Goodwin, D. G. Green, M. W. Guy andA. Voller, Br. J. exp. Path.53, 40 (1972).Google Scholar
  2. 4.
    S. B. Ackerman andJ. R. Seed, Clin. exp. Immun, in press (1976).Google Scholar
  3. 5.
    P. K. Murray, G. M. Urquhart, M. Murray andF. W. Jennings, Trans. R. Soc. trop. Med. Hyg.67, 267 (1973).Google Scholar
  4. 6.
    B. M. Greenwood, H. C. Whittle andD. H. Molyneux, Trans. R. Soc. trop. Med. Hyg.67, 846 (1973).Google Scholar
  5. 7.
    G. M. Urquhart, M. Murray, P. K. Murray, F. W. Jennings andElma Bate, Trans. R. Soc. trop. Med. Hyg.67, 528 (1973).Google Scholar
  6. 8.
    J. A. Longstaffe, Trans. R. Soc. trop. Med. Hyg.68, 150 (1974).Google Scholar
  7. 9.
    H. H. Stibbs andJ. R. Seed, Experientia29, 1563 (1973).Google Scholar
  8. 10.
    H. H. Stibbs, personal communication (1974).Google Scholar
  9. 11.
    L. V. Devoino, L. S. Korovina andR. Ilyutchenok, Eur. J. Pharmac.4, 441 (1968).Google Scholar
  10. 12.
    L. V. Devoino andR. Ilutchenok, Eur. J. Pharmac.4, 449 (1968).Google Scholar
  11. 13.
    L. V. Devoino, O. F. Eremina andR. Ilutchenok, Neuropharmacology9, 67 (1970).Google Scholar
  12. 14.
    S. B. Ackerman andJ. R. Seed, Infect. Immun.13, 1 (1976).Google Scholar

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • S. B. Ackerman
    • 1
  • J. R. Seed
    • 1
  1. 1.Laboratory of Parasitology, Department of BiologyTulane UniversityNew OrleansUSA

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