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Pharmaceutisch Weekblad

, Volume 13, Issue 5, pp 210–214 | Cite as

In vitro andin vivo comparison of creams containing dithranol 0.5%

  • J. J. W. Ros
  • Y. G. Van der Meer
  • D. De Hoop
  • W. J. A. De Kort
  • P. Van Andel
Articles
  • 31 Downloads

Abstract

In anin vitro model, the release and penetration through a silicon membrane of different cream formulations and ointments containing 0.5% dithranol were studied. The results indicated that the method is not suitable for predictingin vivo release and penetration. Experiments with rabbits showed that the degree of skin irritation produced by a hospital-prepared product containing 0.5% dithranol was comparable to that of a commercial product. Clinical efficacy and side-effects of these two products were investigated in a double-blind left-right comparative study in 35 patients with chronic plaque psoriasis. The two creams proved to be equally effective and showed the same incidence of side-effects.

Keywords

Clinical trials Creams Dithranol Drug evaluation Drug release Irritation tests Penetration Psoriasis Side effects 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • J. J. W. Ros
    • 1
  • Y. G. Van der Meer
    • 1
  • D. De Hoop
    • 2
  • W. J. A. De Kort
    • 2
  • P. Van Andel
    • 2
  1. 1.Hospital Pharmacy Gelderse ValleiGA Bennekomthe Netherlands
  2. 2.Psoriasisdagbehandelingscentrum Midden-NederlandPD Edethe Netherlands

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