Agents and Actions

, Volume 18, Issue 1–2, pp 155–158 | Cite as

FMLP-activated neutrophils evoke histamine release from mast cells

  • R. Fantozzi
  • S. Brunelleschi
  • A. Rubino
  • S. Tarli
  • E. Masini
  • P. F. Mannaioni
Histamine and Immunology

Abstract

Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    N.S. Ranadive andC.G. Cochrane,Mechanism of histamine release from mast cells by cationic protein (band 2) from neutrophil lysosomes, J. Immun.106, 506–516 (1971).PubMedGoogle Scholar
  2. [2]
    H. Ohmori, K. Komoriya, A. Azuma, S. Kurozumi andY. Hashi Oto,Xanthine oxidase-induced histamine release from isolated rat peritoneal mast cells: involvement of hydrogen peroxide, Biochem. Pharmac.28, 333–334 (1979).CrossRefGoogle Scholar
  3. [3]
    W.R. Henderson, E.Y. Chi andS.J. Klebanoff,Eosinophil peroxidase-induced mast cell secretion, J. Exp. Med.152, 265–279 (1980).CrossRefPubMedGoogle Scholar
  4. [4]
    O. Stendahl, L. Molin andM. Lindroth,Granulocyte-mediated release of histamine from mast cells, Int. Archs Allergy appl. Immun.70, 277–284 (1983).Google Scholar
  5. [5]
    B.I. Coble, M. Lindroth, L. Molin andO. Stendahl,Histamine release from mast cells during phagocytosis and interaction with activated neutrophils, Int. Archs Allergy appl. Immun.75, 32–37 (1984).Google Scholar
  6. [6]
    R. Fantozzi, S. Brunelleschi, L. Giuliattini, P. Blandina, E. Masini, G. Cavallo andP.F. Mannaioni,Mast cell and neutrophil interactions: a role for superoxide anion and histamine, Agents and Actions16, 260–264 (1985).PubMedGoogle Scholar
  7. [7]
    R. Fantozzi, S. Brunelleschi, G. Banchelli Soldaini, P. Blandina, E. Masini, L. Raimondi andP.F. Mannaioni,N-Formylmethionyl-leucyl-phenylalanine: different releasing effects on human neutrophils and rat mast cells, Agents and Actions13, 218–221 (1983).PubMedGoogle Scholar
  8. [8]
    D. Lorenz, P.W. Lücker, W.H. Mennicke andN. Wetzelsberger,Pharmacokinetic studies with silymarin in human serum and bile, Meth. and Find. Exptl. Clin. Pharmacol.6, 655–661 (1984).Google Scholar
  9. [9]
    A. Bindoli, L. Cavallini andN. Siliprandi, On the mechanism of antiperoxidative action of silymarin on biological membranes. In:Interdisciplinary trends in surgery (Xth Congress of the European Federation of the International College of Surgeons, Milan, 26–29 June 1977), pp. 813–818. Edizioni Minerva Medica, Torino 1979.Google Scholar
  10. [10]
    J.P. Bennett, B.D. Gomperts andE. Wollenweber,Inhibitory effects of natural flavonoids on secretion from mast cells and neutrophils, Arzneim.-Forsch./Drug Res.31, 433–437 (1981).Google Scholar

Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • R. Fantozzi
    • 1
  • S. Brunelleschi
    • 1
  • A. Rubino
    • 1
  • S. Tarli
    • 1
  • E. Masini
    • 1
  • P. F. Mannaioni
    • 1
  1. 1.Department of Preclinical and Clinical PharmacologyUniversity of FlorenceFlorenceItaly

Personalised recommendations