Advertisement

Pharmaceutisch Weekblad

, Volume 11, Issue 4, pp 132–133 | Cite as

The place of quinolones in the treatment of respiratory tract infections

  • J. W. M. van der Meer
Therapeutic Interventions in Lower Respiratory Tract Infections
  • 12 Downloads

Abstract

The new quinolones are rarely indicated for the treatment of community-acquired pneumonia in the normal host. For nosocomial pneumonia they may be used when a Gram-negative aerobic bacillus is the causative organism. Pneumonia in the compromised host may be an indication for a quinolone. In the hypogammaglobulinaemic patient withHaemophilus influenzae pneumonia, the quinolones may be used, especially when the organism is resistant to other drugs. For the neutropenic patient with Gram-negative pneumonia the quinolones may be a good choice. However, more clinical studies are needed. In treatment for exacerbations of chronic bronchitis, failures seem to be associated with pneumococcal infections. For patients with cystic fibrosis, the quinolones offer successful ambulatory treatment for theirPseudomonas andHaemophilus infections. The information regarding dosage schedules is still incomplete.

Keywords

Bronchitis Cross infection Immunocompromised host Pneumonia Quinolones 

References

  1. 1.
    Meyer RD. Activity of quinolones againstLegionella. Quinol Bull 1988;2:13–4.Google Scholar
  2. 2.
    Garcia-Rodriguez JA. Activity of quinolones against mycobacteria (in vitro andin vivo). Quinol Bull 1988;4:21–5.Google Scholar
  3. 3.
    Maesen FPV, Davies BI, Teengs JP. Pefloxacin in acute exacerbations of chronic bronchitis. J Antimicrob Chemother 1986;16:379–88.Google Scholar
  4. 4.
    Bosso JA, Black PG, Matsen JM. Ciprofloxacin versus tobramycin plus azlocillin in pulmonary exacerbations in adult patients with cystic fibrosis. Am J Med 1987;82 (Suppl 4A):180–4.PubMedGoogle Scholar
  5. 5.
    Hodson ME, Roberts CM, Butland RJA, Smith MJ, Batten JC. Oral ciprofloxacin compared with conventional intravenous treatment forPseudomonas aeruginosa infection in adults with cystic fibrosis. Lancet 1987;1:235.PubMedGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1989

Authors and Affiliations

  • J. W. M. van der Meer
    • 1
  1. 1.Division of General Internal MedicineUniversity Hospital NijmegenHB Nijmegenthe Netherlands

Personalised recommendations