Pharmaceutisch Weekblad

, Volume 11, Issue 4, pp 121–123 | Cite as

Two different dosages of ciprofloxacin in patients with respiratory tract infections

  • T. Brutel de la Rivière
  • M. S. M. Daniëls-Bosman
  • G. P. M. ten Velde
Therapeutic Interventions in Lower Respiratory Tract Infections


Fifty-one patients with chronic obstructive lung disease with a proven bacterial respiratory tract infection were treated with ciprofloxacin 500 mg twice daily or 750 mg twice daily. Both dosages were given orally for approximately 10 days. The higher dosage showed a reduced amount of reinfections and relapses (19% and 16% versus 5% and 0%). The overall results were the same in both groups. Adverse reactions were mild: nausea and visual disturbances were seen in five patients. Eights patients had slight liver test abnormalities. In one patient a seizure occurred. All adverse reactions were of a temporary nature.


Ciprofloxacin Pulmonary diseases, chronic obstructive Respiratory tract infections 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1989

Authors and Affiliations

  • T. Brutel de la Rivière
    • 1
  • M. S. M. Daniëls-Bosman
    • 2
  • G. P. M. ten Velde
    • 1
  1. 1.Department of PulmonologyUniversity Hospital MaastrichtBX Maastrichtthe Netherlands
  2. 2.Department of Clinical MicrobiologyUniversity Hospital Maastrichtthe Netherlands

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