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, Volume 41, Issue 1–2, pp 86–87 | Cite as

Efficacy of ipriflavone in the prevention and treatment of postmenopausal osteoporosis

  • Attila B. Kovács
Papers Presented at the Joint Meeting of the European Inflammation Society and Hungarian Biochemical Society Balatonaliga, Hungary, 19–21 May, 1993

Abstract

The efficacy of ipriflavone was investigated in a 1-year double-blind, placebo-controlled, parallel group clinical trial. Ninety-one postmenopausal women completed the study, 41 received ipriflavone and 50 placebo treatment. After six months the bone mineral density of the L2–L4 vertebral region increased in the ipriflavone-treated group (0.015 g/cm2), whereas it decreased in the placebo-treated group. The differences between the treatment groups were statistically significant. Our results support the efficacy of ipriflavone in the treatment of postmenopausal osteoporosis. Since the positive effect was more pronounced after 6 months, the possibility of an intermittent ipriflavone treatment might be taken into consideration in the future.

Key words

Ipriflavone Postmenopausal osteoporosis 

References

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    K. Notoya, R. Tsukuda, K. Yoshida and S. Taketomi,Stimulatory effect of Ipriflavonc on Formation of Bone-Like Tissue in Rat. Bone Marrow Stromal Cell Culture. Clacified Tissue International Vol. 51, Supplement 1, 1992. S16-S40.Google Scholar
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    J.-Y. Reginster,Management of High Turnover Osteoporosis with Calcitonin, Bone, Vol. 13, Supplement 2, 1992, S37-S40.CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1994

Authors and Affiliations

  • Attila B. Kovács
    • 1
  1. 1.Clinical Development GroupCHINOIN Pharmaceutical and Chemical Works Co. Ltd.BudapestHungary

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