Agents and Actions

, Volume 16, Issue 3–4, pp 208–210 | Cite as

Evidence for an anaphylactic reaction-induced gastric acid secretion from the isolated stomach of the mouse

  • I. Szelenyi
  • S. Postius
Histamine and Gastrointestinal Tract

Abstract

Underin vitro circumstances, ovalbumin, administered serosally, caused a definite acid secretory response in the isolated whole stomach of sensitized mice. Acid secretion induced by challenge was inhibited by cimetidine or by pretreatment with disodium cromoglycate. It remained, however, unchanged by mepyramine or atropine. It is likely that a local histamine release caused by an anaphylactic reaction of type 1 might be involved in the pathogenesis of certain kinds of digestive diseases, i.e. peptic ulcer.

Keywords

Histamine Peptic Ulcer Cimetidine Atropine Gastric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    C. André, B. Moulinier, F. André andS. Daniere,Evidence for anaphylactic reactions in peptic ulcer and varioliform gastritis, Ann. Allergy51, 325–328 (1983).PubMedGoogle Scholar
  2. [2]
    I. Szelenyi,An isolated mammalian stomach preparation for studying the effect of substances on gastric acid secretion, Arzneimittel-Forsch./Drug Res.31, 998–1000 (1981).Google Scholar
  3. [3]
    P.F. Shapiro andA.C. Ivy,Gastric ulcer. IV. Experimental production of gastric ulcer by local anaphylaxis, Arch. Int. Med.38, 237–258 (1926).Google Scholar
  4. [4]
    J. Siegel,Gastrointestinal ulcer — Arthus reactionl, Ann. Allergy32, 127–132 (1974).PubMedGoogle Scholar
  5. [5]
    F. André andC. André,Gastric ulcer induced by mucosal anaphylaxis in ovalbumin-sensitized Praomys (Mastomys) natalensis, Am. J. Path.102, 133–135 (1981).PubMedGoogle Scholar
  6. [6]
    J.C. Foreman andJ.L. Mongar,The role of the alkaline earth ions in anaphylactic histamine secretion, J. Physiol., Lond.224, 753–769 (1972).Google Scholar
  7. [7]
    C.H. Cho andC.J. Pfeiffer,Gastrointestinal ulceration in the guinea pig, in response to dimaprit, histamine, and H 1-and H 2-blocking agents, Dig. Dis. Sci.26, 306–311 (1981).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • I. Szelenyi
    • 1
  • S. Postius
    • 1
  1. 1.Department of PharmacologyHeumann-PharmaNurembergFRG

Personalised recommendations