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Cluster of an erythromycin-resistant variant of the Spanish multiply resistant 23F clone ofStreptococcus pneumoniae in South Africa

  • K. P. Klugman
  • T. J. Coffey
  • A. Smith
  • A. Wasas
  • M. Meyers
  • B. G. Spratt
Notes

Abstract

A multiply resistant serotype 23F pneumococcus was cultured from a 3-year-old child with otitis media and five carriers at the child's day-care centre in South Africa. Attempts to eradicate carriage with mupirocin failed. The strains were identical to the spanish clone of multiply resistant pneumococci by serotype, antimicrobial susceptibility pattern, restriction analysis of the penicillin-binding protein 1A, 2B and 2X genes and by multilocus enzyme electrophoresis. The data suggest that this clone has acquired erythromycin resistance. A possible link between the index case and residence of a family member in Spain was found.

Keywords

Erythromycin Otitis Medium Antimicrobial Susceptibility Mupirocin Susceptibility Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1994

Authors and Affiliations

  • K. P. Klugman
    • 1
  • T. J. Coffey
    • 3
  • A. Smith
    • 1
  • A. Wasas
    • 1
  • M. Meyers
    • 2
  • B. G. Spratt
    • 3
  1. 1.Department of Medical MicrobiologyUniversity of the Witwatersrand and South African Institute for Medical ResearchJohannesburgSouth Africa
  2. 2.van Drimmelin and PartnersJohannesburgSouth Africa
  3. 3.Microbial Genetics Group, School of Biological SciencesSussex UniversitySussexUK

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