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Pharmaceutisch Weekblad

, Volume 13, Issue 3, pp 119–122 | Cite as

Allergic contact dermatitis caused by naturally occurring quinones

  • Jean-Pierre Lepoittevin
  • Claude Benezra
Reviews

Abstract

Quinones play a major role in allergic contact dermatitis caused by plants. The principal allergens are benzoquinones or naphthoquinones but also compounds, such as catechols and other phenolic or flavonoid compounds, which are bioconverted intoortho-quinones orpara-quinones. The high electrophilic reactivity of these compounds toward nucleophilic residues of proteins associated with lipophilic properties may explain that they are strong sensitizers. The more important allergens are reported and their structure-activity relationship is discussed.

Keywords

Allergens Bioflavonoids Catechols Dermatitis, contact Haptens Phenols Proteins Quinones 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • Jean-Pierre Lepoittevin
    • 1
  • Claude Benezra
    • 1
  1. 1.Laboratoire de DermatochimieClinique Dermatologique, CHRUStrasbourgFrance

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