Pharmaceutisch Weekblad

, Volume 12, Issue 5, pp 200–204 | Cite as

Dissolution profiles of mesalazine formulationsin vitro

  • L. M. L. Stolk
  • R. Rietbroek
  • E. H. Wiltink
  • J. J. Tukker


In vitro dissolution profiles of three controlled-release mesalazine formulations were determined at pH 1.0, 6.0 and 7.5. A closed-column type dissolution apparatus was used. A reproducible gradual dissolution profile was seen for Pentasa® at all pH values. Dissolution starts immediately and is complete after 20 h. Dissolution profiles at pH 1 and pH 7.5 are much alike and dissolution is faster than at pH 6. The behaviour of Asacol® at different pH values corresponds with the expectations: no release at pH 6 and pH 1, fast release at pH 7.5. Dissolution starts after 1 h and is complete after 3 h. Mesalazine release from Salofalk® tablets at pH 7.5 and pH 6.0 starts after 2 and 3 h, respectively, and is complete after 5 and 10 h. However, after a long lag-time (10 h) mesalazine is also released from Salofalksu® tablets at pH 1 and dissolution is complete after 23 h.


Dissolution Mesalazine Tablets, controlled release 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • L. M. L. Stolk
    • 1
  • R. Rietbroek
    • 2
  • E. H. Wiltink
    • 1
  • J. J. Tukker
    • 2
  1. 1.Pharmacy DepartmentAcademic Medical CentreAZ Amsterdamthe Netherlands
  2. 2.Department of Biopharmaceutics, Faculty of PharmacyUtrecht UniversityGH Utrechtthe Netherlands

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