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Pharmaceutisch Weekblad

, Volume 12, Issue 5, pp 188–189 | Cite as

Comparison of clonazepam sorption to polyvinyl chloride-coated and polyethylene-coated tubings

  • P. M. Hooymans
  • R. Janknegt
  • J. J. H. M. Lohman
Articles

Abstract

The sorption of clonazepam to polyvinyl chloride tubing, polyethylene-coated tubing and to a polyethylene syringe was determined. Pumping of clonazepam (5 mg/48 ml) through the polyvinyl chloride tubing with flow rates of 2 ml/h and 4 ml/h resulted in a reduction of the clonazepam concentration to about 40% and 55% of the original strength after 0.6 h, respectively. This value was 55% at a flow rate of 2 ml/h and a clonazepam concentration of 10 mg/48 ml. The effluent clonazepam concentration increased gradually after an infusion period of 1 h. Sorption of clonazepam to the polyethylene syringe and to the tubing coated on the inside with polyethylene does not occur. The use of polyethylene-coated administration sets is recommended for intravenous administration of clonazepam.

Keywords

Clonazepam Polyethylenes Polyvinyl chloride Sorption Syringes Tubing 

References

  1. 1.
    Trissel LA. Handbook on injectable drugs. 5th ed. Bethesda: American Society of Hospital Pharmacists, 1988:237–9.Google Scholar
  2. 2.
    Nation RL, Hackett LP, Dusci LJ. Uptake of clonazepam by plastic intravenous infusion bags and administration sets. Am J Hosp Pharm 1983;40:1692–3.Google Scholar
  3. 3.
    Van Huffelen AC, Magnus O. De behandeling van de status epilepticus met clonazepam [Treatment of status epilepticus with clonazepam]. Ned Tijdschr Geneeskd 1976;41:1734–8.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • P. M. Hooymans
    • 1
  • R. Janknegt
    • 1
  • J. J. H. M. Lohman
    • 1
  1. 1.Department of Clinical PharmacyMaasland HospitalMB Sittardthe Netherlands

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