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, Volume 11, Issue 6–7, pp 550–553 | Cite as

Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: The inhibitory effect of prostacyclin (PGI2)

  • Giovanni Camussi
  • Ciro Tetta
  • Giuseppe Segoloni
  • M. Chiara Deregibus
  • Federico Bussolino
Proceedings of the 3rd European Workshop on Inflammation, Paris, 2–3 March 1981 Phospholipase: Role in Cellular Activation


Soluble and phagocytic stimuli released PAF-acether from PMN leucocytes, as determined by chromatography and bioassay by platelet aggregation. The same material caused aggregation of human and rabbit PMN leucocytesin vitro which was inhibited by ETYA and PGI2. PGI2 also inhibited PAF-acether release by PMN leucocytes and,in vivo, PGI2 abolished not only PAF-acether-induced, but also immune complex or C5a-induced thrombocytopenia and neutropenia in rabbits. These data suggest that PAF-acether may be involved in activation of both platelets and PMN leucocytesin vivo.


Neutropenia Thrombocytopenia Platelet Aggregation Immune Complex Prostacyclin 
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Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • Giovanni Camussi
    • 1
  • Ciro Tetta
    • 1
  • Giuseppe Segoloni
    • 1
  • M. Chiara Deregibus
    • 1
  • Federico Bussolino
    • 1
  1. 1.Laboratorio di Immunopatologia, Cattedra di NefrologiaOsp. S.G. BattistaTurinItaly

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