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European Child & Adolescent Psychiatry

, Volume 3, Issue 2, pp 59–71 | Cite as

Piracetam in developmental reading disorders: A review

  • Colin R. Wilsher
  • Eric A. Taylor
Article

Abstract

This paper reviews the studies that have examined piracetam, the first of the nootropic drugs, as a treatment for developmental reading disorder. In various studies, 751 children have completed treatment in controlled double-blind trials using standardised tests of reading as outcome measures. Quantitative and qualitative review suggests that the findings are best interpreted as showing a statistical superiority of piracetam over placebo. Mechanism of action and clinical significance are discussed. The effect size is modest, but the drug is well tolerated and the balance of benefit over hazard is encouraging for future use.

Keywords

Placebo Clinical Significance Standardise Test Piracetam Qualitative Review 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Cet article fait part des études qui ont examiné le piracetam, le premier des produits “nootropiques” comme traitement des troubles développementaux de la lecture. Dans différentes études, 751 enfants ont effectué un traitement basé sur des essais en double aveugle, en utilisant des tests standardisés comme mesure des performances de lecture. Les études quantitatives et qualitatives suggèrent que les résultats sont interprétés comme montrant une supériorité statistique du piracetam sur le placebo. Les mécanismes d'action et la signification clinique sont discutés. Les effets sont modestes mais le produit est bien toléré et la supériorité des effets bénéfiques est encourageante pour un usage futur.

Zusammenfassung

In dieser Übersichtsarbeit werden Studien analysiert, die die Auswirkung von Piracetam im Rahmen der Behandlung der Leseschwäche untersucht haben. Piracetam kam als erstes der nootropen Medikamente auf den Markt. In verschiedenen Studien haben insgesamt 751 Kinder eine medikamentöse Behandlung in kontrollierten Doppelblindstudien unter Anwendung standardisierter Lesetests abgeschlossen. Die quantitative und qualitative Auswertung zeigt, daß die Befunde am ehesten im Sinne einer statistischen Überlegenheit des Piracetams gegenüber Placebo zu werten sind. Die Wirkungsweise und die klinische Bedeutung werden diskutiert. Die Wirkung ist gering; das Medikament wird gut vertragen. Die positive Bilanz unter Berücksichtigung der Nebenwirkungen ist im Hinblick auf den weiteren Einsatz dieses Medikamentes ermutigend.

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Copyright information

© Hogrefe & Huber Publishers 1994

Authors and Affiliations

  • Colin R. Wilsher
    • 1
    • 2
  • Eric A. Taylor
    • 3
  1. 1.College Visiting Fellow, Department of PsychologyUniversity College of North WalesUK
  2. 2.UCB Pharma Ltd.WatfordUK
  3. 3.Institute of PsychiatryDenmark HillUK

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