Advertisement

Pharmaceutisch Weekblad

, Volume 14, Issue 5, pp 321–324 | Cite as

Assessment of trace element compatibility in total parenteral nutrition infusions

  • M. C. Allwood
  • M. Greenwood
Practice/Case Reports

Abstract

The application of X-ray energy dispersive spectroscopy to detect elements collected from TPN mixtures on membrane filters has been investigated. Many simple total parenteral nutrition mixtures prepared aseptically in large bags can be stored for extended periods. Trace elements are normally excluded from such bags, because not enough is known about their long-term stability and compatibility in total parenteral nutrition mixtures. Assessing the compatibility of many trace elements by conventional methods that rely on detecting concentration changes is extremely difficult. Analysis of precipitates from total parenteral nutrition mixtures confirmed that the proposed method was capable of identifying a number of elements from the mixture in complex precipitates, including calcium, phosphorus, iron, copper and selenium.

Keywords

Compatibility Parenteral feeding Precipitation Spectrometry, X-ray dispersive 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    American Medical Association. Guidelines for essential trace element preparations for parenteral use. A statement by an expert panel. JAMA 1979;241:2051–4.Google Scholar
  2. 2.
    Kingsnorth AN. Trace elements in adult total-parenteral nutrition. Br J Parent Ther 1984;5:8–22.Google Scholar
  3. 3.
    Boddapati S, Yang K, Murty R. Intravenous solution compatibility and filter-retention characteristics of trace element preparations. Am J Hosp Pharm 1981;38:1731–6.PubMedGoogle Scholar
  4. 4.
    Allwood MC. The compatibility of four trace elements in total parenteral nutrition infusions. Int J Pharm 1983;16:57–63.CrossRefGoogle Scholar
  5. 5.
    Allwood MC. Compatibility and stability of TPN mixtures in big bags. J Clin Hosp Pharm 1984;9:181–98.PubMedGoogle Scholar
  6. 6.
    Bates CG, Greiner G, Gegenheimer A. Precipitate in admixtures of new amino acid injection. Am J Hosp Pharm 1984;41:1312.PubMedGoogle Scholar
  7. 7.
    Ganther HE, Kraus RJ. Chemical stability of selenious acid in total parenteral nutrition solutions containing ascorbic acid. J Parent Enter Nutr 1989;13:185–8.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1992

Authors and Affiliations

  • M. C. Allwood
    • 1
  • M. Greenwood
    • 1
  1. 1.Medicines Research Unit and Department of Life SciencesDerbyshire College of Higher EducationMickleoverUK

Personalised recommendations