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Pharmaceutisch Weekblad

, Volume 14, Issue 5, pp 297–304 | Cite as

Didanosine, a new antiretroviral drug

A review
  • R. M. E. Franssen
  • P. L. Meenhorst
  • C. H. W. Koks
  • J. H. Beijnen
Reviews

Abstract

In this article the literature about didanosine, an antiretroviral drug, is reviewed. The mechanism of action, biochemical pharmacology, pharmacokinetics, and clinical results of phase-I trials are discussed. Serious adverse effects such as pancreatitis and peripheral neuropathy have occurred in these trials. An antiretroviral effect was observed in terms of an increase in CD4+ lymphocytes and a decrease in p24 antigen levels in HIV-infected individuals. Didanosine seems to be a promising drug against HIV infection, but knowledge about its clinical efficacy is scanty.

Keywords

Biochemistry Didanosine Drug evaluation Pharmacokinetics Pharmacology Side effects 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1992

Authors and Affiliations

  • R. M. E. Franssen
    • 1
  • P. L. Meenhorst
    • 2
  • C. H. W. Koks
    • 1
  • J. H. Beijnen
    • 1
  1. 1.Department of PharmacySlotervaart HospitalEC AmsterdamThe Netherlands
  2. 2.Department of Internal MedicineSlotervaart HospitalThe Netherlands

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