Phospholipase C-induced neural tube defects in the mouse embryo
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Mouse embryo neurulae were exposed in vitro to phospholipase C to examine the role of carbohydrate-rich extracellular material (ECM) during neurulation. Exposure of embryos to this agent for 12 h resulted in failure of closure of the neural tube. Ultrastructural examination revealed an absence of ECM from regions of the neural tube which failed to close.
KeywordsNeural Tube Mouse Embryo Neural Tube Defect Ultrastructural Examination Extracellular Material
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