, Volume 36, Issue 10, pp 1217–1219 | Cite as

Phospholipase C-induced neural tube defects in the mouse embryo

  • K. S. O'Shea
  • M. H. Kaufman


Mouse embryo neurulae were exposed in vitro to phospholipase C to examine the role of carbohydrate-rich extracellular material (ECM) during neurulation. Exposure of embryos to this agent for 12 h resulted in failure of closure of the neural tube. Ultrastructural examination revealed an absence of ECM from regions of the neural tube which failed to close.


Neural Tube Mouse Embryo Neural Tube Defect Ultrastructural Examination Extracellular Material 
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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • K. S. O'Shea
    • 1
  • M. H. Kaufman
    • 1
  1. 1.Department of AnatomyCambridge(England)

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