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Experientia

, Volume 36, Issue 10, pp 1206–1207 | Cite as

Constituents of Egyptian Euphorbiaceae. IX. Irritant and cytotoxic ingenane esters fromEuphorbia paralias L.

  • M. D. Sayed
  • A. Riszk
  • F. M. Hammouda
  • M. M. El-Missiry
  • E. M. Williamson
  • F. J. Evans
Specialia

Summary

The irritant and cytotoxic constituents of the latex ofEuphorbia paralias L. were separated from the hydrocarbon fraction by means of solvent partition. 3 new ingenane esters were identified from the toxic ether fraction. The major compound was 3-angelyl-20-deoxyingenol and the 2 minor compounds were 3-hexanoyl-20-deoxyingenol and 3-angelylingenol. These compounds were of a similar potency to podophyllin in the inhibition of3H-thymidine uptake by TLX/5 mouse lymphoma cells. In addition the compounds produced a persistent erythema of the mouse ear in sub-microgram doses.

Keywords

Ether Ester Lymphoma Hydrocarbon Lymphoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • M. D. Sayed
    • 1
  • A. Riszk
    • 1
  • F. M. Hammouda
    • 1
  • M. M. El-Missiry
    • 1
  • E. M. Williamson
    • 1
  • F. J. Evans
    • 1
  1. 1.Pharmaceutical Science LaboratoryNational Research CentreCairo(Egypt)

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