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Pharmaceutisch Weekblad

, Volume 8, Issue 1, pp 42–45 | Cite as

The effect of the 4-quinolone enoxacin on plasma theophylline concentrations

  • W. J. A. Wijnands
  • T. B. Vree
  • C. L. A. Van Herwaarden
Quinolones in Perspective

Abstract

In patients treated concomitantly with theophylline and enoxacin, a broad spectrum antibacterial agent for oral administration, unexpectedly high plasma theophylline concentrations were observed. In six patients receiving intravenous aminophylline under controlled conditions, enoxacin was started in a daily dose of 800 or 1200 mg. Plasma theophylline concentrations increased from 8.4 ± 2.4 mg/l to 15.0 ± 5.1 mg/l at day 3 of co-administration. Total body clearance of theophylline decreased significantly, whereas renal clearance and protein binding did not change. When enoxacin, 800 mg daily, was administered to seven patients with a stable chronic obstructive pulmonary disease, who were on long-term theophylline treatment a significant increase in plasma theophylline concentrations occurred as well: elimination half-life was prolonged. It is concluded that the rise of plasma theophylline concentrations is caused by a reduced metabolic clearance of theophylline. If concomitant use of both drugs is necessary, monitoring of plasma theophylline concentration and adjustment of the theophylline dose is recommended, to avoid toxicity.

Key words

Drug interactions Enoxacin Lung disease, obstructive Metabolic clearance Theophylline 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1986

Authors and Affiliations

  • W. J. A. Wijnands
    • 1
  • T. B. Vree
    • 2
  • C. L. A. Van Herwaarden
    • 1
  1. 1.Department of Pulmonary DiseaseMedical Centre DekkerswaldCA Heilige LandstichtingThe Netherlands
  2. 2.Department of Clinical Pharmacy, St. Radboud HospitalCatholic University of NijmegenHB NijmegenThe Netherlands

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