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Pharmaceutisch Weekblad

, Volume 8, Issue 1, pp 40–41 | Cite as

Place of quinolones in the therapeutic armoury

  • B. Van Klingeren
Quinolones in Perspective
  • 11 Downloads

Abstract

On the basis of antimicrobial activity, resistance development, pharmacokinetics, side effects and pre-clinical results, the applicability of the quinolones ciprofloxacin, enoxacin, norfloxacin, ofloxacin and pefloxacin is assessed. These quinolones seem especially useful in infections in hospitalized patients, in gonococcal infections and in urinary tract infections. Also salmonellosis and shigellosis might be indications for quinolones.

Key words

Drug evaluation, preclinical Drug resistance Pharmacokinetics Quinolones Side effects 

References

  1. 1.
    Smith JI. Awakening the slumbering potential of the 4-quinolone antibacterials. Pharm J 1984:229–305.Google Scholar
  2. 2.
    Shah PM, ed. Reports on gyrase inhibitions. Quinolones Bull, October 1984, April, June and November 1985.Google Scholar
  3. 3.
    Chapman SI, Speller DC, Reeves DS. Resistance to ciprofloxacin. Lancet 1985;12:39.Google Scholar
  4. 4.
    Humphreys H, Mulvihill E. Ciprofloxacin-resistantStaphylococcus aureus. Lancet 1985;2:383.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1986

Authors and Affiliations

  • B. Van Klingeren
    • 1
  1. 1.Laboratory for ChemotherapyNational Institute of Public Health and Environmental HygieneBA BilthovenThe Netherlands

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