Experientia

, Volume 36, Issue 4, pp 423–425 | Cite as

Effect of substrates on the mechanical performance of rhesus monkey papillary muscle

  • T. R. Snow
Article
First Online:
  • 12 Downloads

Summary

This study examines the effect of different substrates on mechanical performance of excised papillary muscles from rhesus monkeys which had been divided into a control group and an experimental group fed a high fat diet for 5 months prior to sacrifice. The results show that performance is affected by available substrate for both groups. The performance of the experimental group was depressed relative to control with the short chain fatty acid, butyrate (C4), producing a monotonically decreasing force-frequency response. Relative to other mammals, isolated rhesus papillary muscles exhibited a protracted treppe which was sensitive to β-adrenergic blockade with propranolol.

Keywords

Propranolol Butyrate Mechanical Performance Papillary Muscle Short Chain Fatty Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 2.
    K.L. Zierler, Circulation Res.38, 459 (1976).CrossRefPubMedGoogle Scholar
  2. 3.
    J.B. Chapman, J. gen. Physiol.59, 135 (1972).CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    J.R. Neely, K.M. Whitmer and S. Mochizuki, Circulation Res.38, (suppl. 1) 22 (1976).Google Scholar
  4. 5.
    A.J. Liedke, S. Nellis and J.R. Neely, Circulation Res.43, 652 (1978).CrossRefGoogle Scholar
  5. 6.
    H. Stam and W. Breeman, Life Sci.23, 1905 (1978).CrossRefPubMedGoogle Scholar
  6. 7.
    T.R. Snow, Am. J. Physiol.235, H144 (1978).Google Scholar
  7. 8.
    J.B. Chapman and C.L. Gibbs, Cardiovas. Res.8, 656 (1974).CrossRefGoogle Scholar
  8. 9.
    T. Sugano, N. Oshino and B. Chance, Biochem. biophys. Acta347, 340 (1974).PubMedGoogle Scholar
  9. 10.
    M.L. Entman, Adv. nucleotide Res.4, 163 (1974).Google Scholar
  10. 11.
    P.J. Manning, T.B. Clarkson and H.B. Lofland, Exp. molec. Path.14, 75 (1971).CrossRefPubMedGoogle Scholar
  11. 12.
    T.R. Snow, Experientia32, 1550 (1976).CrossRefPubMedGoogle Scholar
  12. 13.
    W.A. Frezza and O.H.L. Bing, Am. J. Physiol.231, 1620 (1976).PubMedGoogle Scholar
  13. 14.
    T.R. Snow and P.B. Bressler, J. molec. cell. Card.9, 595 (1977).CrossRefGoogle Scholar
  14. 15.
    B.R. Jewell and J.M. Rovell, J. Physiol.235, 715 (1973).CrossRefPubMedPubMedCentralGoogle Scholar
  15. 16.
    B.J.R. Pitts, C.A. Tate, B. van Winkle, J.M. Wood and M.L. Entman, Life Sci.23, 391 (1978).CrossRefPubMedGoogle Scholar
  16. 17.
    A.L. Shug, J.H. Thomsen, J.D. Folts, N. Bittar, M.I. Klein, J.R. Koke and P.J. Huth, Archs Biochem. Biophys.187, 25 (1978).CrossRefGoogle Scholar
  17. 18.
    J.T. Whitmer, J.A. Idell-Wenger, M.J. Rovetto and J.R. Neely, J. biol. Chem.253, 4305 (1978).PubMedGoogle Scholar
  18. 19.
    R. Kaufmann, R. Bayer, T. Fürniss, H. Krause and H. Tritthart, J. molec. cell. Card.6, 543 (1974).CrossRefGoogle Scholar
  19. 20.
    G.A. Langer, J. molec. cell. Card.1, 203 (1970).CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • T. R. Snow
    • 1
  1. 1.Department of PhysiologyDuke University Medical CenterDurhamUSA

Personalised recommendations