Advertisement

Experientia

, Volume 36, Issue 4, pp 377–379 | Cite as

Structure and toxicity of the alkaloids of Russian comfrey (Symphytum x uplandicum Nyman), a medicinal herb and item of human diet

  • C. C. J. Culvenor
  • M. Clarke
  • J. A. Edgar
  • J. L. Frahn
  • M. V. Jago
  • J. E. Peterson
  • L. W. Smith
Specialia

Summary

Eight pyrrolizidine alkaloids of hepatotoxic type have been indentified in leaves ofSymphytum × uplandicum The combined alkaloids exhibit chronic hepatotoxicity in rats.

Keywords

Alkaloid Juvenile Hormone Pyrrolizidine Alkaloid Anhydrous Potassium Carbonate Total Plasma Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 2.
    L.D. Hills, Comfrey, Past, Present and Future. Faber and Faber, London 1976.Google Scholar
  2. 3.
    H.E. Kirschner, Nature's Healing Grasses. H. C. White Publications, Riverside 1960.Google Scholar
  3. 4.
    L.B. Bull, C.C.J. Culvenor and A.T. Dick, The Pyrrolizidine Alkaloids. North-Holland, Amsterdam 1968, a) p. 234, b) p. 143, c) p. 163.Google Scholar
  4. 5.
    C.C.J. Culvenor and L.W. Smith, Aust. J. Chem.8, 556 (1955).CrossRefGoogle Scholar
  5. 6.
    E. Pedersen, Arch. Pharm. Chem. sci. Ed.3, 55 (1975).Google Scholar
  6. 7.
    T. Furuya and K. Araki, Chem. pharm. Bull., Japan16, 2512 (1968).CrossRefGoogle Scholar
  7. 8.
    T. Furuya and M. Hikichi, Phytochemistry10, 2217 (1971).CrossRefGoogle Scholar
  8. 9.
    M.E. Fowler and R. Schoental, J. Am. vet. med. Ass.150, 1305 (1967).Google Scholar
  9. 10.
    R. Schoental, M.E. Fowler and A. Coady, Cancer Res.30, 2127 (1970).PubMedGoogle Scholar
  10. 11.
    C.C.J. Culvenor, J.A. Edgar, M.V. Jago, A. Outteridge, J.E. Peterson and L.W. Smith, Chemico-Biol. Interact.12, 299 (1976).CrossRefGoogle Scholar
  11. 12.
    M.V. Jago, Aust. J. exp. Biol. med. Sci.48, 93 (1970).CrossRefPubMedGoogle Scholar
  12. 13.
    E. McLean, Pharmac. Rev.22, 429 (1970).Google Scholar
  13. 14.
    O. Mohabbat, R.N. Srivastava, M.S. Younos, G.G. Sediq, A.A. Merzad and G.N. Aram, Lancet2, 269 (1976).CrossRefPubMedGoogle Scholar
  14. 15.
    B.N. Tandon, R.K. Tandon, H.D. Tandon, M. Narndranathan and Y.K. Joshi, Lancet2, 271 (1976).CrossRefPubMedGoogle Scholar
  15. 16.
    P.T. Hooper and W.A. Scanlan, Aust. vet. J.53, 109 (1977).CrossRefPubMedGoogle Scholar
  16. 17.
    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man, vol. 10. International Agency for Research on Cancer, Lyon 1976.Google Scholar
  17. 18.
    National Cancer Institute. Bioassay of Lasiocarpine for Possible Carcinogenesis, Technical report No. 39, DHEW (NIH). 78-839, Bethesda, Maryland 1978.Google Scholar
  18. 19.
    M.V. Jago and J.E. Peterson, unpublished data.Google Scholar
  19. 20.
    A. Saifer and T. Marven, Clin. Chem.12, 414 (1966).PubMedGoogle Scholar
  20. 21.
    Anon, Z. klin. Chem. klin. Biochem.8, 658 (1970).Google Scholar
  21. 22.
    I. Hirono, H. Mori and M. Haga, J. nat. Cancer Inst.61, 865 (1978); I. Hirono, personal communication.Google Scholar
  22. 23.
    R. Schoental, J. Path.77, 485 (1959).CrossRefGoogle Scholar
  23. 24.
    M.V. Jago, Aust. J. exp. Biol. med. Sci.48, 94 (1970).CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • C. C. J. Culvenor
    • 1
  • M. Clarke
    • 1
  • J. A. Edgar
    • 1
  • J. L. Frahn
    • 1
  • M. V. Jago
    • 1
  • J. E. Peterson
    • 1
  • L. W. Smith
    • 1
  1. 1.CSIRO, Division of Animal HealthParkvilleAustralia

Personalised recommendations