Pharmacokinetics of fluconazole in pediatric patients

  • K. W. Brammer
  • P. E. Coates
Current Topic: Article


The pharmacokinetic properties of fluconazole were studied in more than 100 pediatric patients, including 12 premature neonates. The volume of distribution and the rate of elimination differed significantly from the values reported for adults. The volume of distribution varied with age, being greatest during the neonatal period (1.18 to 2.25 l/kg) and decreasing by young adulthood to a value similar to that reported for adults (0.7 l/kg). With the exception of neonates, fluconazole clearance was generally more rapid in children than in adults, with a mean plasma elimination half-life of just over 20 h for all pediatric age groups. In neonates, fluconazole was eliminated slowly, with a mean elimination half-life of 88.6 h at birth, 67.5 h approximately one week later and 55.2 approximately two weeks after birth. Fluconazole appeared to be well absorbed from the gastrointestinal tract. These pharmacokinetic results, taken in conjunction with the corresponding data for adults, provide a sound basis for establishing appropriate fluconazole dosage recommendations for pediatric patients.


Internal Medicine Gastrointestinal Tract Pediatric Patient Fluconazole Pharmacokinetic Property 
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  1. 1.
    Viscoli C, Castagnola E, Fioredda F, Ciravegna B, Barigione G, Terragna A Fluconazole in the treatment of candidiasis in immunocompromised children. Antimicrobial Agents and Chemotherapy 1991, 35: 365–367.PubMedGoogle Scholar
  2. 2.
    Bode S, Pedersen-Bjergaard L, Hjelt K Candida albicans septicemia in a premature infant successfully treated with oral fluconazole. Scandinavian Journal of Infectious Diseases 1992, 24: 673–675.PubMedGoogle Scholar
  3. 3.
    Lee JW, Seibel NL, Amantea M, Whitcomb P, Pizzo PA, Walsh TJ Safety and pharmacokinetics of fluconazole in children with neoplastic diseases. Journal of Pediatrics 1992, 120: 987–993.PubMedGoogle Scholar
  4. 4.
    Saxen H, Hoppu K, Pohjavuori M Pharmacokinetics of fluconazole in very low birthweight infants during the first two weeks of life. Clinical Pharmacology and Therapeutics 1993, 54: 269–277.PubMedGoogle Scholar
  5. 5.
    Macrae PV Quantitative analysis of the antifungal agent fluconazole by capillary gas chromatography with ion trap detection. In: Reid E (ed): Methodological surveys in biochemistry and analysis. Royal Society of Chemistry, London, 1990, p. 145–152.Google Scholar
  6. 6.
    Wallace JE, Harris SC, Gallegos J, Foulds G, Chen TJH, Rinaldi MG Assay of fluconazole by high performance liquid chromatography with a mixed-phase column. Antimicrobial Agents and Chemotherapy 1992, 36: 603–606.PubMedGoogle Scholar
  7. 7.
    Harris SC, Wallace JE, Foulds G, Rinaldi MG Assay of fluconazole by megabore capillary gas-liquid chromatography with nitrogen-selective detection. Antimicrobial Agents and Chemotherapy 1989, 33: 714–716.PubMedGoogle Scholar
  8. 8.
    Milsap RL, Szefler SJ Special pharmacokinetic considerations in children. In: Evans WE, Schentag JJ, Jusko WJ (ed): Applied pharmacokinetics. Applied Therapeutics Publishing, Spokane, WA, 1986, p. 294–330.Google Scholar
  9. 9.
    Brammer KW, Farrow PR, Faulkner JK Pharmacokinetics and tissuepenetration of fluconazole in humans.Reviews of Infectious Diseases 1990, 12, Supplement 3: 318–326.Google Scholar
  10. 10.
    Brammer KW, Coakley AJ, Jezequel SG, Tarbit MH The disposition and metabolism of [14C] fluconazole in humans. Drug Metabolism and Disposition 1991, 19: 764–767.PubMedGoogle Scholar
  11. 11.
    Grant SM, Clissold SP Fluconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses. Drugs 1990, 39: 877–916.PubMedGoogle Scholar
  12. 12.
    Paap CM, Nahat MC Clinical pharmacokinetics of antibacterial drugs. Clinical Pharmacokinetics 1990, 19: 280–318.PubMedGoogle Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1994

Authors and Affiliations

  • K. W. Brammer
    • 1
  • P. E. Coates
    • 1
  1. 1.Clinical Research DepartmentPfizer Central ResearchSandwichUK

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