Hematological toxicity of tetrachloroethylene in mice
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Female C57/BL/6 × DBA/2 hybrid mice were exposed to two concentrations (270 and 135 ppm) of tetrachloroethylene (PER) in inhalation chambers for 6 h/day, 5 days per week, up to 11.5 weeks (270 ppm) and 7.5 weeks (135 ppm), respectively, followed by a 3-week exposure-free period. In the peripheral blood a reduction of lymphocytes/monocytes and of neutrophils was observed with an almost complete regeneration in the exposure-free period. A reticulocytosis during and also after the exposure indicated a compensatory reaction in the erythroid cell system. Bone marrow pluripotent stem cells (CFU-S) were not affected up to 7.5 weeks. Erythroid committed cells (BFU-E and CFU-E) did react, with a reduction of CFU-E numbers at 7.5 and 11.5 weeks. A slight reduction of CFU-C numbers at 7.5 weeks indicated, in accordance with the peripheral blood data, a disturbance of the granulocytic cell series as well.
Key wordsTetrachloroethylene (PER) Mice Inhalation Haemopoietic stem cells
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- Henschler D (1988) Tetrachlorethen. In: Gesundheitsschädliche Arbeitsstoffe. DFG. VCH WeinheimGoogle Scholar
- National Toxicology Program (NTP) (1986) Toxicology and carcinogenesis studies of tetrachloroethylene (perchloroethylene) in F344/N rats and B6C3F1 mice (inhalation studies). Tech Rep Ser No 311, US Dept Health & Human Services, Research Triangle Park NC 27709, USAGoogle Scholar
- Rampy L, Quast J, Leong B, Gehring P (1978) Results of a longterm inhalation toxicity study on rats of a perchloroethylene (tetrachloroethylene) formulation. Toxicol Res Lab, Health and Environ Res, Dow Chemical USA, Midland, MI, USAGoogle Scholar