Archives of Toxicology

, Volume 67, Issue 2, pp 148–150

Poisoning by toxic honey in Turkey

  • Nurhayat Sütlüpmar
  • Afife Mat
  • Yurdagül Satganoglu
Letter to the Editors

Abstract

One of the food intoxications encountered in Turkey is the case caused by toxic honey made by bees fromRhododendron species.R.luteum andR.ponticum are the two species which grow in the north regions of Turkey. Grayanotoxins, mainly Grayanotoxin I (Andromedotoxin) occurring only in Ericaceae plants, are the compounds responsible for poisoning. In this investigation, the diagnosis and treatment of 11 cases of poisoning admitted to Kartal Occupational Diseases Hospital between 1983 and 1988 are presented. The results of the light microscopic and chemical analysis of toxic honey samples are compared with those of the ordinary honey samples and the extract ofRhododendron leaves.

Key words

Toxic honey Poisoning Rhododendron Andromedotoxin Grayanotoxin 

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References

  1. Baytop T (1984), Türkiye'de bitkilerle tedavi (Therapy with medicinal plants in Turkey). Ist. Üniv. Yay. No. 3255, Sanal Matbaasi, Istanbul, p 178Google Scholar
  2. Bucak AM (1938) Zehirli bal (Toxic honey). Farmakoloğ 8: 33–40Google Scholar
  3. Çakaloğlu Y, Kaymakoğlu S, Erden S, Çalangu S (1988) Bal zehirlenmesi ve tedavisi (Honey intoxication and its treatment). Tip Fak Mecm 49: 94–97Google Scholar
  4. Constantine Jr, GH, Shet K, Catalfomo P (1967) Grayanotoxin I. Occurrence in additional Ericaceae species. J Pharm Sci 56: 1518–1519PubMedGoogle Scholar
  5. Cooper MR, Johnson AW (1984) Poisonous plants in Britain and their effects on animals and man. Ministry of Agriculture Fisheries and Food, London, pp 110–112Google Scholar
  6. Godin P (1954) A new spray reagent for paper chromatography of polyols and cetoses. Nature 174: 134Google Scholar
  7. Hikino H, Ohizumi Y, Konno C, Hashimoto K, Wakasa H (1979) Subcronic toxicity of Ericaceous toxins andRhododendron leaves. Chem Pharm Bull 27: 874–879PubMedGoogle Scholar
  8. Karakaya AE (1977), Zehirli balin Grayanotoksin içeriği veRhododendron türleri ile ilişkisinin araştirilmasi (Grayanotoxin content of the toxic honey and research on its relation with theRhododendron species. J Fac Pharm Ankara 7: 111–115Google Scholar
  9. Omurtag AC, Evliya B, Aydin A, Akin A, Erinç N, Dolgun Y (1973) Yurdumuz zehirli ballannin laboratuvar diyagnostiği üzerinde araştirma (The research for the laboratory diagnosis of poisonous honey of Turkey). J Fac Pharm Ankara 3: 55–70Google Scholar
  10. Pulewka P (1949) Andromedotoxin ihtiva eden bal ve bunun zehirliligini. tayin için biyolojik bir metod hakkinda (Über Andromedotoxinhaltigen Honig und eine biologische Methode zur Bestimmung seiner Giftigkeit). Türk Hijyen ve Tecrübi Biyoloji Dergisi 9: 7–17Google Scholar
  11. Scott PM, Coldwell BB, Wiberg GS (1971) Grayanotoxins. Occurrence and analysis in honey and a comparison of toxicities in mice. Fd Cosmet Toxicol 9: 179–184CrossRefGoogle Scholar
  12. Shindler H (1962) Über Acethylandromedol (Andromedotoxin) in verschiedenen Ericaceen, insbesondere inRhododendron, und seine annähernde Bestimmung. Planta Med 10: 232–237Google Scholar
  13. Stevens PF (1978)Rhododendron L. In: Davis PH (ed) Flora of Turkey and the East Aegean Islands, vol. 6. University Press, Edinburgh, pp 90–94Google Scholar
  14. Tallent WH, Riethof ML, Horning EC (1957) Studies on the occurrence and structure of Acetylandromedol (Andromedotoxin), J Am Chem Soc 79: 4548–4554Google Scholar
  15. Ungan A (1941) Şimali Anadolu'nun zehirli bali (Toxic honey of Northern Anatolia). Türk Hijyen ve Tecrübi Biyoloji Dergisi 2: 161Google Scholar
  16. Wood Jr, HB, Stomberg UL, Keresztesy JC, Horning EC (1954) Andromedotoxin. A potent hypotensive agent fromRhododendron maximum, J Am Chem Soc 76: 5689–5692CrossRefGoogle Scholar
  17. Zymalkowsky F, Pachaly P, Keller S (1968) Die Bestimmung von Acetylandromedol (Grayanotoxin I) in Extrakten vonRhododendron ponticum. Planta Med 17: 8–13Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Nurhayat Sütlüpmar
    • 1
  • Afife Mat
    • 1
  • Yurdagül Satganoglu
    • 2
  1. 1.Department of Pharmacognosy, Faculty of PharmacyUniversity of IstanbulIstanbulTurkey
  2. 2.Kartal Occupational Diseases HospitalIstanbulTurkey

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