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Archives of Toxicology

, Volume 67, Issue 2, pp 145–147 | Cite as

Effect of Sairei-to on gentamicin nephrotoxicity in rats

  • I. Ohno
  • T. Shibasaki
  • H. Nakano
  • H. Matsuda
  • H. Matsumoto
  • T. Misawa
  • F. Ishimoto
  • O. Sakai
Letter to the Editors

Abstract

The effect of Sairei-to, an oriental traditional medicine, against gentamicin nephrotoxicity was examined in gentamicin nephrotoxicity rat models. Gentamicin nephrotoxicity was induced by s. c. injection of gentamicin (100 mg/kg/day, for 3 days) in male Sprague-Dawley rats. Renal functions of two rat groups were compared, one eating rat chow containing 2.5% Sairei-to, the other eating normal rat chow. Sairei-to administration reduced the increase of urinary N-acetyl-β-D-glucosaminidase (NAG) and protein excretion, and decreased creatinine clearance induced by gentamicin. Gentamicin increased renal cortical malondialdehyde (MDA) concentration in normal diet group but not in the Sairei-to diet group. The renal cortical gentamicin concentration was not different between the two groups. In conclusion, Sairei-to shows reno-protective action against gentamicin nephrotoxicity, possibly through its anti-oxidant action.

Key words

Sairei-to Gentamicin Nephrotoxicity Malondialdehyde 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • I. Ohno
    • 1
  • T. Shibasaki
    • 1
  • H. Nakano
    • 1
  • H. Matsuda
    • 1
  • H. Matsumoto
    • 1
  • T. Misawa
    • 1
  • F. Ishimoto
    • 1
  • O. Sakai
    • 1
  1. 1.Second Department of Internal MedicineJikei University School of MedicineTokyoJapan

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