A study on the buffering activity of the human rectum
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The buffering activity of the human rectum was evaluated in various pilot studies, using a rectal lumen perfusion method. Quantitative alkaline and acid secretion was measured, respectively, by direct titration according to the pH-stat method. The change in composition of the perfusate with regard to the test drug benzoate and the concentration HCO 3 − was detected. The pilot studies suggest that rectal mucosa is capable of neutralizing a pH deviating from the physiological value within a remarkably short time. In the acid region, at least a part of the alkalizing activity is the result of HCO 3 − secretion. It has been shown that this process is stimulated by the H− as well as Cl− ions. In the basic region neutralization very likely occurs by means of H− secretion.
KeywordsAcid-base imbalance Buffers Hydrogen Hydrogen carbonate Neutralization Perfusion, rectal Rectum Secretion
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