Histamine content in human gastric mucosa: Its relation to the pentagastrin-stimulated acid secretion and to selective-gastric vagotomy with drainage
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No correlation between histamine content of corpus mucosa and maximum response to pentagastrin existed in normal human subjects and in patients suffering from gastric diseases. Normal histamine concentrations were found in duodenal ulcer patients who did not show any reduction in acid output despite complete vagotomy. A relatively low mucosal histamine content was determined in a patient with proven Zollinger-Ellison syndrome. However one year after complete selective-gastric vagotomy the corpus mucosal histamine concentrations were considerably increased. This is the first case in the literature that the histamine content of the human gastric mucosa was altered.
KeywordsHistamine Duodenal Ulcer Acid Output Ulcer Patient Pentagastrin
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