, Volume 37, Issue 9, pp 913–917

The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep

  • D. Schneider-Helmert
  • G. A. Schoenenberger


The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b. wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs. The results were: longer sleep duration and a higher quality of sleep with fewer interruptions; slightly more REM-sleep, but no day-time sedation or other side effects though the sleep enhancing capacity was seen for up to 6 h of night sleep. Sleep-promoting effects occurred only in the second hour after injection, in the first hour a slight arousing effect was indicated. The study corroborates the findings of previous investigations in healthy subjects and shows that DSIP has a normalizing influence on human sleep regulation.


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Copyright information

© Birkhüuser Verlag 1981

Authors and Affiliations

  • D. Schneider-Helmert
    • 1
    • 2
  • G. A. Schoenenberger
    • 1
    • 2
  1. 1.Psychiatric ClinicResearch Department/Sleep LaboratoriesKönigsfelden(Switzerland)
  2. 2.Research Division, Department of Surgery/Research Department KantonsspitalUniversity of BaselBasel(Switzerland)

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