Archives of Toxicology

, Volume 66, Issue 7, pp 496–502 | Cite as

Spontaneous neoplasms in aged sprague-dawley rats

  • Manik Chandra
  • Michael G. I. Riley
  • Dale E. Johnson
Original Investigations


Incidence of neoplastic lesions in untreated Sprague-Dawley rats (1340 males and 1329 females) used as controls in 17 carcinogenicity studies are tabulated and evaluated. In male rats, the most common neoplasms were benign pheochromocytomas and keratoacanthomas (4.0% in each case) followed by pancreatic islet cell adenomas (3.7%), thyroid parafollicular cell adenomas (3.6%), fibromas and squamous cell papillomas of the skin and hepatocellular adenomas (2.0% in each), malignant lymphoma lymphocytic (1.9%), histiocytic sarcomas (1.4%), and adrenal cortical adenomas (1.2%). In female rats, the most common neoplasms were of mammary gland origin (31.3%: fibroadenoma 19.0%, adenocarcinomas 8.8%, and adenomas 3.5%) followed by thyroid parafollicular cell adenomas (2.9%), uterine endometrial stromal polyps (2.6%), adrenal cortical adenomas (1.9%), malignant lymphoma lymphocytic (1.6%), fibromas in the skin (1.3%), and pancreatic islet cell adenoma (1.1%). Metastases were observed from pheochromocytomas, hepatocellular carcinomas, nephroblastomas, renal pelvis transitional cell carcinoma, interstitial cell tumor and seminoma of the testes, Zymbal's gland adenocarcinomas, and mammary adenocarcinomas.

Key words

Spontaneous Tumor Neoplasm Rodent Rat 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Chandra M, Frith CH (1992a) Spontaneous neoplasms in aged control Fischer 344 rats. Cancer Lett 62: 49–56PubMedGoogle Scholar
  2. Chandra M, Frith CH (1992b) Spontaneous neoplasms in B6C3F1 mice. Toxicol Lett 60: 91–98PubMedGoogle Scholar
  3. Chandra M, Frith CH (1992c) Spontaneous neoplasms in aged CD-1 mice. Toxicol Lett (in press)Google Scholar
  4. Chandra M, Riley MGI, Johnson DE (1991) Clear cell carcinoma in the trachea of a rat. Lab Anim Sci 41: 262–264PubMedGoogle Scholar
  5. Gregson RL, Lewis DJ, Abbott DP (1984) Spontaneous neoplasms of the laboratory rats. Vet Pathol 21: 292–299PubMedGoogle Scholar
  6. Gross L, Dreyfuss Y (1979) Spontaneous tumors in Sprague-Dawley and Long-Ewans rats in their F1 hybrids: carcinogenic effect of total-body X-irradiation. Proc Natl Acad Sci 76: 5910–5913PubMedGoogle Scholar
  7. Gould DH (1977) Mesotheliomas of the tunica vaginalis propria and peritonium in Fischer rats. Vet Pathol 14: 372–379PubMedGoogle Scholar
  8. Kaspareit-Rittinghausen J, Deerberg F, Rapp K, Wcislo A (1990) Mortality and tumour incidence of Han: SPRD rats. Z Versuchstierkd 33: 23–28PubMedGoogle Scholar
  9. Kinkle VHJ (1971) Spontantumoren bei Sprague-Dawley Ratten. Z Versuchstierk 13: 97–100Google Scholar
  10. Krinke G, Naylor DC, Schmid S, Frohlich E, Schnider K (1985) The incidence of naturally-occurring primary brain tumors in the laboratory rat. J Comp Pathol 95: 175–192PubMedGoogle Scholar
  11. Lewis DJ (1987) Ovarian neoplasms in the Sprague-Dawley rats. Environ Health Perspect 73: 77–90PubMedGoogle Scholar
  12. Maekawa A, Onodera H, Tanigawa H, Furuta K, Matsuoka C, Kanno J, Ogiu T, Hayashi Y (1986) Spontaneous neoplastic and non-neoplastic lesions in aging Donryu rats. Jpn J Cancer Res 77: 882–890PubMedGoogle Scholar
  13. McComb DJ, Kovacs K, Beri J, Zak F (1984) Pituitary adenoma in old Sprague-Dawley rats: a histologic, ultrastructural, immunocytochemical study. N Natl Cancer Inst 73: 1143–1166Google Scholar
  14. Prejean JD, Peckham JC, Casey AE, Griswold DP, Weisburger EK, Weisburger JH (1973) Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res 33: 2768–2773PubMedGoogle Scholar
  15. Robertson JL, Garman RH, Fowler EH (1982) Spontaneous cardiac tumors in eight rats. Vet Pathol 19: 30–37PubMedGoogle Scholar
  16. Ross MH, Bras G (1965) Tumor incidence patterns and nutrition in the rat. J Nutr 87: 245–259PubMedGoogle Scholar
  17. Schardein JD, Fitzgerald, Kaump DH (1968) Spontaneous tumors in Holtzman-Source rats of various ages. Pathol Vet 5: 238–252PubMedGoogle Scholar
  18. Suzuki H, Mohr U, Kimmerle G (1979) Spontaneous endocrine tumors in Sprague-Dawley rats. J Cancer Res Clin Oncol 95: 187–196PubMedGoogle Scholar
  19. Turusov V, Mohr U (1990) Pathology of tumours in laboratory animals. Tumours of the rat. International Agency for Research on Cancer, Lyon, FranceGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Manik Chandra
    • 1
  • Michael G. I. Riley
    • 1
  • Dale E. Johnson
    • 1
  1. 1.Wilbur G. Toxicology Laboratories, Medical Research DivisionAmerican Cyanamid CompanyPearl RiverUSA

Personalised recommendations