Agents and Actions

, Volume 9, Issue 4, pp 333–336 | Cite as

Protective role of ceruloplasmin in inflammation

  • Charles W. Denko
Immunosuppression and Inflammation


Experimental inflammation in copper Cu)-deficient rats is greater than that induced in controls eating normal diet. Cu-supplementation of the Cu-deficient diet results in a reduced swelling, down to normal levels. Injection of the naturally occurring acute phase reactant, ceruloplasmin (Cp) a Cu-bearing serum protein, also results in reduction of experimental inflammation. Since a rise in serum Cp occurs in normal pregnancy this protective anti-inflammatory action in normal pregnancy this protective anti-inflammatory action of Cp is proposed as an explanation for the widely-observed phenomenon of spontaneous control of rheumatoid arthritis in pregnancy.


Copper Rheumatoid Arthritis Arthritis Normal Level Acute Phase 
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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • Charles W. Denko
    • 1
    • 2
  1. 1.Department of MedicineCase Western Researve UniversityClevelandUSA
  2. 2.Scott Research LaboratoryFairview General HospitalClevelandUSA

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