Agents and Actions

, Volume 9, Issue 4, pp 333–336 | Cite as

Protective role of ceruloplasmin in inflammation

  • Charles W. Denko
Immunosuppression and Inflammation
Received:

Abstract

Experimental inflammation in copper Cu)-deficient rats is greater than that induced in controls eating normal diet. Cu-supplementation of the Cu-deficient diet results in a reduced swelling, down to normal levels. Injection of the naturally occurring acute phase reactant, ceruloplasmin (Cp) a Cu-bearing serum protein, also results in reduction of experimental inflammation. Since a rise in serum Cp occurs in normal pregnancy this protective anti-inflammatory action in normal pregnancy this protective anti-inflammatory action of Cp is proposed as an explanation for the widely-observed phenomenon of spontaneous control of rheumatoid arthritis in pregnancy.

Keywords

Copper Rheumatoid Arthritis Arthritis Normal Level Acute Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    F.W. Putnam,The Plasma Proteins, Structure, Function and Genetic Control, vol. 1 (Ed. F.W. Putnam; Academic Press, New York, 1975), chapter 2, pp. 85–87.Google Scholar
  2. [2]
    C.L. Fisher andC.W. Gill,Acute Phase Proteins, in:Serum Protein Abnormalities, Diagnostic and Clinical Aspects (eds. S.E. Ritzman and J.C. Daniels; Little Brown, Boston, 1975), pp. 331–350.Google Scholar
  3. [3]
    C.W. Denko andP. Gabriel, Serum Proteins-Transferrin, Ceruloplasmin, Albumin, α1 Acid Glycoprotein, α1 Antitrypsin - in Rheumatic Disorders. To be published in Journal of Rheumatology.Google Scholar
  4. [4]
    M. Petricevic, K. Wanek andC.W. Denko,A New Mechanical Method for Measuring Rat Paw Edema, Pharmacology16, 153–158 (1978).PubMedGoogle Scholar
  5. [5]
    C.W. Denko andM.W. Whitehouse,Experimental Inflammation Induced by Naturally Occurring Microcrystalline Calcium Salts, J. Rheum.3, 54–62 (1976).PubMedGoogle Scholar
  6. [6]
    G.P. Rodman (ed.),Primer on the Rheumatic Diseases, 7th ed. (The Arthritis Foundation, New York, 1973).Google Scholar
  7. [7]
    M.C. Lawrence andS.E. Ritzman,Immunology Workshop Manual (Behring Diagnostics, Somerville, New York, undated).Google Scholar
  8. [8]
    A.W. Ford-Hutchinson, M.Y. Insley, P.N.C. Elliott, E.A. Sturgess andM.J.H. Smith,Antiinflammatory Activity in Human Plasma, J. Pharm. Pharmacol.25, 881–886 (1973).PubMedGoogle Scholar
  9. [9]
    I.L. Bonta andJ. Noordhoek,Anti-Inflammatory Mechanism of Inflamed Tissue Factor, Agents and Actions3, 348–356 (1973).PubMedGoogle Scholar
  10. [10]
    E. Misaka, K. Matsuda, K. Kobayashi, Y. Endo, T. Kojima andY. Lizuka,Purification and Characterization of an Anti-Inflammatory Factor (AIF) from Bovine Serum, Agents and Actions8, 442–451 (1978).CrossRefPubMedGoogle Scholar
  11. [11]
    A.J. Lewis,A Comparison of the Anti-Inflammatory Effects of Copper Aspririnate and Other Copper Salts in Rat and Guinea Pig, Agents and Actions8, 244–250 (1978).CrossRefPubMedGoogle Scholar
  12. [12]
    M.W. Whitehouse,Ambivalent Role of Copper in Inflammatory Disorders, Agents and Actions6, 201–205 (1976).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • Charles W. Denko
    • 1
    • 2
  1. 1.Department of MedicineCase Western Researve UniversityClevelandUSA
  2. 2.Scott Research LaboratoryFairview General HospitalClevelandUSA

Personalised recommendations