Pharmaceutisch Weekblad

, Volume 14, Issue 6, pp 349–352 | Cite as

Administration of oral chloral hydrate to paediatric patients undergoing magnetic resonance imaging

  • Crisanto L. Ronchera
  • Luis Martí-Bonmatí
  • Cecilio Poyatos
  • José Vilar
  • N. Víctor Jiménez


Sedation is frequently required in children undergoing magnetic resonance imaging (MRI). 172 Paediatric patients (82 female and 90 male, age 42±26 months, weight 14.7±5.6 kg) entered an open, non-comparative, prospective study to assess the utilization of oral chloral hydrate. Chloral hydrate syrup (70 mg/ml) was administered 20–30 min prior to the procedure. Effective sedation was reached in 80.3% with an average initial dose of 55 mg/kg and in 93.6% with an average total dose of 65 mg/kg. Significant differences in effectivity were correlated with the dose (54±11 mg/kg in failure cases versus 66±16 mg/kg in effective cases; p <0.05) and diagnosis (effectivity falls to 62.5% and 76.0% in children with medullar tumours and encephalic white matter alterations, respectively; p <0.01). Average sleep induction time was 30±19 min, and average duration of sleep was 62±24 min. Adverse reactions occurred in 4.7%, with nausea, vomiting and stomach pain being the most common side-effects (3.5%). Multivariate statistical analysis selects total dose and age into the discriminant function, with a 100% relative percentage of correct classification. A simple method for optimizing the chloral hydrate dose in children is proposed: the dose in mg/kg is calculated as half the age in months + 50.


Children Chloral hydrate Dosage Sedation 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1992

Authors and Affiliations

  • Crisanto L. Ronchera
    • 1
  • Luis Martí-Bonmatí
    • 2
  • Cecilio Poyatos
    • 2
  • José Vilar
    • 2
  • N. Víctor Jiménez
    • 1
  1. 1.Department of PharmacyHospital Dr. PesetValenciaSpain
  2. 2.Department of Diagnostic RadiologyHospital Dr. PesetValencia

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