Experientia

, Volume 52, Issue 6, pp 564–567 | Cite as

Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes

  • H. Haraguchi
  • I. Ohmi
  • H. Masuda
  • Y. Tamura
  • K. Mizutani
  • O. Tanaka
  • W. -H. Chou
Research Articles

Abstract

Astilbin and neoastilbin, dihydroflavonol rhamnosides fromEngelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against bothdl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.

Key words

Engelhardtia chrysolepis astilbin neoastilbin taxifolin aldose reductase aldehyde reductase NADH oxidase 

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Copyright information

© Birkhäuser Verlag 1996

Authors and Affiliations

  • H. Haraguchi
    • 1
  • I. Ohmi
    • 1
  • H. Masuda
    • 2
  • Y. Tamura
    • 2
  • K. Mizutani
    • 2
  • O. Tanaka
    • 2
  • W. -H. Chou
    • 3
  1. 1.Faculty of EngineeringFukuyama UniversityFukuyama(Japan)
  2. 2.Biology and Chemistry LaboratoryMaruzen Pharmaceutical Co. Ltd.Fukuyama(Japan)
  3. 3.South China Institute of BotanyThe Academy of Science of ChinaGuangzhou(China)

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