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, Volume 25, Issue 1–2, pp 191–194 | Cite as

Failure of PAF-acether to inducein vivo neutrophil migration

  • F. Q. Cunha
  • N. E. Heluy-Neto
  • A. Klein
  • G. E. P. Souza
  • S. H. Ferreira
Platelets and Thrombosis


The ability of PAF-acether (platelet activating factor, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to induce neutrophil migration was tested in the peritoneal cavities of rats and guinea-pigs and in rat skin air pouches. PAF-acether, at doses of 2 and 5 μg per animal, did not promote significant neutrophil migration. The ability of PAF-acether antagonists to inhibit carrageenin induced neutrophil migration in rat abdominal cavities was also investigated. Carrageenin is a substance described to cause the release of endogenous PAF-acether. Neutrophil migration was not affected by PAF-antagonists. These observations challenge the possible role of PAF-acether as a neutrophil chemotactic factorin vivo.


Peritoneal Cavity Abdominal Cavity Activate Factor Platelet Activate Platelet Activate Factor 
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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • F. Q. Cunha
    • 1
    • 2
  • N. E. Heluy-Neto
    • 1
    • 2
  • A. Klein
    • 1
    • 2
  • G. E. P. Souza
    • 1
    • 2
  • S. H. Ferreira
    • 1
    • 2
  1. 1.Department of Pharmacology of the Faculty of MedicineUniversity of São PauloRibeirão PretoBrazil
  2. 2.the Faculty of Pharmaceutical Sciences of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil

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