Failure of PAF-acether to inducein vivo neutrophil migration
- 13 Downloads
The ability of PAF-acether (platelet activating factor, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to induce neutrophil migration was tested in the peritoneal cavities of rats and guinea-pigs and in rat skin air pouches. PAF-acether, at doses of 2 and 5 μg per animal, did not promote significant neutrophil migration. The ability of PAF-acether antagonists to inhibit carrageenin induced neutrophil migration in rat abdominal cavities was also investigated. Carrageenin is a substance described to cause the release of endogenous PAF-acether. Neutrophil migration was not affected by PAF-antagonists. These observations challenge the possible role of PAF-acether as a neutrophil chemotactic factorin vivo.
KeywordsPeritoneal Cavity Abdominal Cavity Activate Factor Platelet Activate Platelet Activate Factor
Unable to display preview. Download preview PDF.
- A. J. Wardlaw, M. R. C. P. Wardlaw and A. B. Kay,PAF-acether is a potent chemotactic factor for human eosinophils. J. of Allergy and Clinical Immunol77 (supl), 236 (1986).Google Scholar
- B. M. Czarnetzki and J. Benveniste,Effect of synthetic PAF-acether on human neutrophil function. Les colloques de l'Inserm Pharmacology of inflammation and Allergy. (Eds. F. Russo Marie, B. B. Vergaftig and J. Benveniste). INSERM100, 105–109 (1981).Google Scholar
- D. M. Humphrey, R. N. Pinckard, L. M. Mcmanus and D. J. Hanahan,Intradermal neutrophil infiltrates induced by 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholyne (AGEPC). Fed. Proceedings40, 1003 (1981).Google Scholar
- B. B. Lorenzetti, G. E. P. Souza, F. Q. Cunha and S. H. Ferreira,Anti-inflammatory effects of BN-52021. Proc. of 2nd Symposium “There is a Case for PAF-Acether Antagonists”. Paris, 1988.Google Scholar
- P. C. Wilkinson,Cellular accumulation and inflammation. InTextbook of Immunopharmacology (Ed. M. M. Dale and J. C. Foreman) pp. 217–232. Blackwell Scientific Publications, Oxford 1984.Google Scholar
- L. Parente and R. J. Flower,The generation of lyso-PAF in experimental inflammation. InInflammatory Mediators (Ed. G. A. Higgs and T. J. Williams), pp. 65–71. Macmillan Press, London 1985.Google Scholar