Advertisement

Pharmaceutisch Weekblad

, Volume 7, Issue 3, pp 104–108 | Cite as

Determination of the stability of tetracycline suspensions by high performance liquid chromatography

  • A. Grobben-Verpoorten
  • Kabala Dihuidi
  • E. Roets
  • J. Hoogmartens
  • H. Vanderhaeghe
Original Articles

Abstract

High performance liquid chromatography was used to examine the stability of tetracycline suspensions, prepared according to the Formulary of the Dutch Pharmacists and the National Formulary v (Belgium). The influence of the nature of the buffer salt, of the pH, and of the temperature and time of storage are discussed. At slightly acid pH (4 to 5.5) and at room temperature suspensions are stable for at least three months.

Keywords

Public Health Internal Medicine Liquid Chromatography High Performance Liquid Chromatography Tetracycline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    The Pharmaceutical Codex, 11th edition. London: The Pharmaceutical Press, 1979.Google Scholar
  2. 2.
    Martindale: The Extra Pharmacopoeia. 27th edition. London: The Pharmaceutical Press, 1977.Google Scholar
  3. 3.
    Formularium der Nederlandse Apothekers. The Hague: Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie, 1982.Google Scholar
  4. 4.
    Formularium Nationale v. Brussel: Algemene Pharmaceutische Bond, 1977, and addendum 1981.Google Scholar
  5. 5.
    The United States Pharmacopeia xx. Rockville: The United States Pharmacopeial Convention, 1980.Google Scholar
  6. 6.
    Doerschuk AP, Bitler BA, McCormick JRD. Reversible isomerizations in the tetracycline family. J Am Chem Soc 1955;77:4687.CrossRefGoogle Scholar
  7. 7.
    Stephens CR/Conover LH, Gordon PN, et al. Epitetracycline. The Chemical relationship between tetracycline and quatrimycin. J Am Chem Soc 1956;78:1515–6.CrossRefGoogle Scholar
  8. 8.
    McCormick JRD, Fox SM, Smith LL, et al. On the nature of the reversible isomerizations occurring in the tetracycline family. J Am Chem Soc 1956;78:3547–8.CrossRefGoogle Scholar
  9. 9.
    McCormick JRD, Fox SM, Smith LL, et al. Studies of the reversible epimerization occurring in the tetracycline family. The preparation, properties and proof of structure of some 4-epitetracyclines. J Am Chem Soc 1957;79:2849–58.CrossRefGoogle Scholar
  10. 10.
    Kaplan MA, Granatek AP, Buckwalter FH. Quatrimycin: preparation and properties. Antibiot Chemother 1957;7:569–76.Google Scholar
  11. 11.
    Remmers EG, Sieger GM, Doerschuk AP. Some observations on the kinetics of the C-4 epimerization of tetracycline. J Pharm Sci 1963;52:752–6.PubMedGoogle Scholar
  12. 12.
    Hussar DA, Niebergall PJ, Sugita ET, Doluisio JT. Aspects of the epimerization of certain tetracycline derivatives. J Pharm Pharmacol 1968;20:539–46.PubMedGoogle Scholar
  13. 13.
    Hoener BA, Sokoloski TD, Mitscher LA, Malspeis L. Kinetics of dehydratation of epitetracycline in solution. J Pharm Sci 1974;63:1901–4.PubMedGoogle Scholar
  14. 14.
    Naggar V, Daabis NA, Motawi MM. Effects of solubilizers on the stability of tetracycline. Pharmazie 1974;29:126–9.PubMedGoogle Scholar
  15. 15.
    Schlecht KD, Frank CW. Dehydratation of tetracycline. J Pharm Sci 1975;64:352–4.Google Scholar
  16. 16.
    Sokoloski TD, Mitscher LA, Yuen PH, Juvarkar JV, Hoener B. Rate and proposed mechanism of anhydrotetracycline epimerization in acid solution. J Pharm Sci 1977;66:1159–65.PubMedGoogle Scholar
  17. 17.
    Yuen PH, Sokoloski TD. Kinetics of concomitant degradation of tetracycline to epitetracycline, anhydrotetracycline, and epianhydrotetracycline in acid phosphate solution. J Pharm Sci 1977;66: 1648–50.PubMedGoogle Scholar
  18. 18.
    Youssef MK, Ibrahim EA, Attia IA. Paper Chromatographie determination of tetracycline. J Pharm Sci 1973;62:1998–2001.PubMedGoogle Scholar
  19. 19.
    Kabala Dihuidi, Roets E, Hoogmartens J, Vanderhaeghe H. Etude de la stabilité en solution méthanolique du chlorhydrate de tétracycline, chlorhydrate d'épi-4-tétracycline, chlorhydrate d'anhydrotétracycline, chlorhydrate d'épi-4-anhydrotétracycline, et chlorhydrate de chlortétracycline. J Pharm Belg 1982;37:35–46.PubMedGoogle Scholar
  20. 20.
    Kassem MA, Sina A, Youssef MK. Über die Haltbarkeit von Tetracyclin und einigen Tetracyclin-Komplexen in Suspensionssystemen. Pharmaz Ztg 1970;115:1036–9.Google Scholar
  21. 21.
    Kabala Dihuidi, Roets E, Hoogmartens J, Vanderhaeghe H. Influence of temperature on the stability of solid tetracycline hydrochloride, measured by highperformance liquid chromatography. J Chromatogr 1982;246:350–5.CrossRefGoogle Scholar
  22. 22.
    Weiss PJ, Andrew ML, Wright WW. Solubility of antibiotics in twenty-four solvents: use in analysis. Antibiot Chemother 1957;7:374–7.Google Scholar
  23. 23.
    European Pharmacopoeia. Vol. 11. Maisonneuve: Sainte-Ruffine, 1974.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1985

Authors and Affiliations

  • A. Grobben-Verpoorten
    • 1
  • Kabala Dihuidi
    • 1
  • E. Roets
    • 1
  • J. Hoogmartens
    • 1
  • H. Vanderhaeghe
    • 1
  1. 1.Institute for Pharmaceutical Sciences, Laboratory for Pharmaceutical ChemistryCatholic University of LeuvenLeuvenBelgium

Personalised recommendations