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Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 296–299 | Cite as

Meta-analysis of randomized controlled trials of antibiotic prophylaxis in abdominal hysterectomy

  • E. W. Wttewaall-Evelaar
Antibiotics in Gynaecology and Obstetrics

Abstract

The value of antibiotic prophylaxis in abdominal hysterectomy was reviewed by meta-analysis. Two independent literature searches (1986–1988) yielded 150 relevant papers, however, only 17 (11.3%) papers met our inclusion criteria. The selected papers described prospective, randomized, blinded, placebo-controlled studies of patients undergoing elective abdominal hysterectomy. In 14 of 17 (82%) trials, first- or second-generation cephalosporins were used. Results pooled confirm that antibiotic prophylaxis will reduce infectious morbidity following elective abdominal hysterectomy. Hospital stay is little affected and significant levels of infectious morbidity remain.

Keywords

Antibiotics Hysterectomy Literature Meta-analysis Pre-operative care 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • E. W. Wttewaall-Evelaar
    • 1
  1. 1.Department of Gynaecology and ObstetricsDiakonessen HospitalKE Utrechtthe Netherlands

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