Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 292–295 | Cite as

Antibiotic prophylaxis in vaginal hysterectomy

Three doses of cefuroxime plus metronidazole versus one dose of ciprofloxacin
  • W. K. Brouwer
  • K. M. Kuiper
  • J. A. A. Hoogkamp-Korstanje
Antibiotics in Gynaecology and Obstetrics

Abstract

The prophylactic efficacy of three intravenous doses of cefuroxime 1,500 mg plus metronidazole 500 mg in vaginal hysterectomy was compared with placebo in a prospective double-blind randomized study. Febrile morbidity occurred in 13 of 26 patients in the placebo group and 0 of 27 patients in the study group. In a second prospective randomized study, the efficacy of intravenous ciprofloxacin (200 mg single dose) was compared with the cefuroxime plus metronidazole regimen. Febrile morbidity was found in 3 of 54 patients in the ciprofloxacin group, but in none of the 58 patients in the cefuroxime plus metronidazole group.

Keywords

Cefuroxime Ciprofloxacin Drug therapy Hysterectomy Metronidazole Pre-operative care 

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References

  1. 1.
    Osborne NG, Wright RC. Effect of preoperative scrub on the bacterial flora of the endocervix and vagina. Obstet Gynecol 1977;50:148–51.PubMedGoogle Scholar
  2. 2.
    Brouwer WK, Hoogkamp-Korstanje JAA, Kuiper KM. Single shot ciprofloxacin, cefuroxim plus metronidazole and placebo as prophylaxis in vaginal hysterectomy. Int J Exp Clin Chemother 1990;3:172–7.Google Scholar
  3. 3.
    Duff P, Park R. Antibiotic prophylaxis in vaginal hysterectomy: a review. Obstet Gynecol 1980;50:193–202.Google Scholar
  4. 4.
    Grossman JH, Greco TP, Minkin MJ, Adams RL, Hierholzer WJ, Andriole OT. Prophylactic antibiotics in gynaecologic surgery. Obstet Gynecol 1979;53:537–44.PubMedGoogle Scholar
  5. 5.
    Hemsell DL, Cunningham G, Kappus S, Nobles B. Cefoxitin for prophylaxis in premenopausal women undergoing vaginal hysterectomy. Obstet Gynecol 1980;56:629–34.PubMedGoogle Scholar
  6. 6.
    Mendelson J, Portnay J, De Saint Victor JR, Gelfand MM. Effect of single and multidose cephradine prophylaxis on infectious morbidity of vaginal hysterectomy. Obstet Gynecol 1979;53:31–5.PubMedGoogle Scholar
  7. 7.
    Mickel A, Curole D, Lewis C. Cefoxitin sodium: double-blind vaginal hysterectomy prophylaxis in premenopausal patients. Obstet Gynecol 1980;56:222–5.PubMedGoogle Scholar
  8. 8.
    Roberts JM, Homesley HD. Low-dose carbenicillin prophylaxis for vaginal and abdominal hysterectomy. Obstet Gynecol 1978;52:83–7.PubMedGoogle Scholar
  9. 9.
    Mathews DD, Agarwal V, Gordon AM, et al. A double-blind trial of single dose chemoprophylaxe with cotrimoxazole during vaginal hysterectomy and repair. Br J Obstet Gynaecol 1979;86:737–40.PubMedGoogle Scholar
  10. 10.
    Hamod KA, Spence MR, Rosenshein NB, et al. Single-dose and multidose prophylaxis in vaginal hysterectomy. A comparison of sodium cepholatin and metronidazole. Am J Obstet Gynecol 1980;136:976–9.PubMedGoogle Scholar

References

  1. 1a.
    McDonald PJ, Sanders R, Turnidge J, et al. Optimal duration of cefotaxime prophylaxis in abdominal and vaginal hysterectomy. Drugs 1988;35(Suppl 2):216–20.PubMedGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • W. K. Brouwer
    • 1
  • K. M. Kuiper
    • 1
  • J. A. A. Hoogkamp-Korstanje
    • 2
  1. 1.Medical Centre LeeuwardenAD Leeuwardenthe Netherlands
  2. 2.Laboratory for Public HealthEN Leeuwardenthe Netherlands

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