Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 292–295

Antibiotic prophylaxis in vaginal hysterectomy

Three doses of cefuroxime plus metronidazole versus one dose of ciprofloxacin
  • W. K. Brouwer
  • K. M. Kuiper
  • J. A. A. Hoogkamp-Korstanje
Antibiotics in Gynaecology and Obstetrics

DOI: 10.1007/BF01967836

Cite this article as:
Brouwer, W.K., Kuiper, K.M. & Hoogkamp-Korstanje, J.A.A. Pharmaceutisch Weekblad Scientific Edition (1990) 12: 292. doi:10.1007/BF01967836


The prophylactic efficacy of three intravenous doses of cefuroxime 1,500 mg plus metronidazole 500 mg in vaginal hysterectomy was compared with placebo in a prospective double-blind randomized study. Febrile morbidity occurred in 13 of 26 patients in the placebo group and 0 of 27 patients in the study group. In a second prospective randomized study, the efficacy of intravenous ciprofloxacin (200 mg single dose) was compared with the cefuroxime plus metronidazole regimen. Febrile morbidity was found in 3 of 54 patients in the ciprofloxacin group, but in none of the 58 patients in the cefuroxime plus metronidazole group.


Cefuroxime Ciprofloxacin Drug therapy Hysterectomy Metronidazole Pre-operative care 

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • W. K. Brouwer
    • 1
  • K. M. Kuiper
    • 1
  • J. A. A. Hoogkamp-Korstanje
    • 2
  1. 1.Medical Centre LeeuwardenAD Leeuwardenthe Netherlands
  2. 2.Laboratory for Public HealthEN Leeuwardenthe Netherlands

Personalised recommendations