Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 289–291 | Cite as

Antibiotic prophylaxis in abdominal hysterectomy, with special reference to the duration of the prophylaxis

  • F. W. Eckenhausen
  • P. L. Jonker
Antibiotics in Gynaecology and Obstetrics


Two consecutive open studies were performed of the efficacy of a prophylactic cefuroxime/metronidazole combination in abdominal hysterectomy. The first group received a 24-h regimen, the second group a single pre-operative dose. The incidence of post-operative wound infections and urinary tract infections were similar in both groups [wound infections in 1/75 versus 2/84 patients (NS), urinary tract infections 4/75 versus 3/84 patients (NS), respectively, in the 24-h group and single-dose group]. No significant differences in other parameters, such as pyrexia and duration of post-operative hospitalization, could be detected.


Antibiotics Cefuroxime Clinical trials Hysterectomy Metronidazole Preoperative care 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • F. W. Eckenhausen
    • 1
  • P. L. Jonker
    • 2
  1. 1.Department of Obstetrics and GynaecologyRefaja HospitalHE Stadskanaalthe Netherlands
  2. 2.Medical DepartmentGlaxo BVML Nieuwegeinthe Netherlands

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