Pharmaceutisch Weekblad

, Volume 12, Issue 6, pp 268–274 | Cite as

Gynaecological infections and strategies for treatment

  • Alphonse J. M. Roex
Antibiotics in Gynaecology and Obstetrics


Frequently, encountered gynaecologic infections and pathogens involved are presented. A review is given of bartholinitis, vulvovaginitis-bacterial vaginosis, candidiasis, trichomoniasis cervicitis and pelvic inflammatory disease:Neisseria gonorrhoeae, Chlamydia trachomatis and herpes simplex virus 2. Of each infection a thorough description of clinical symptoms and diagnostic criteria is followed by up-to-date treatment advices. For vulvovaginitis, cervicitis and pelvic inflammatory disease antifungal and antimicrobial agents, route of administration, the required daily dosage and time of administration are presented in an overview table.


Adnexitis Antibiotics Candidiasis Cervicitis Chlamydia trachomatis Communicable diseases Gynecology Haemophilus vaginalis Neisseria gonorrheae Trichomoniasis Vaginitis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Penn RL. Gynecological and obstetrical infections. In: Reese RE, Gordon Douglas Jr. R, eds. A practical approach to infectious diseases. 2nd ed. Boston: Little, Brown and Company, 1986:385–421.Google Scholar
  2. 2.
    Thadepalli H, Gorbach SL, Keith L. Anaerobic infections of the female genital tract; bacteriologic and therapeutic aspects. Am J Obstet Gynecol 1973;117:1034–40.PubMedGoogle Scholar
  3. 3.
    Ledger WJ. Micro-organisms that cause infection. In: Ledger WJ, ed. Infections in the female. 2nd ed. Philadelphia: Lea & Febiger, 1986:9–34.Google Scholar
  4. 4.
    Adler MW. Epidemiology and treatment of penicillinase-producingNeisseria gonorrhoeae. In: Oriel JD, Harris JRW, eds. Recent advances in sexually transmitted diseases. Edinburgh: Churchill Livingstone, 1986.Google Scholar
  5. 5.
    Chan ASC. Results of treatment with quinolones of sexually transmitted diseases in the far east: a brief summary. Rev Infect Dis 1989;11:S1305–6.PubMedGoogle Scholar
  6. 6.
    Ledger WJ. Antimicrobial agents. In: Ledger WJ, ed. Infections in the female. 2nd ed. Philadelphia: Lea & Febiger, 1986:95–126.Google Scholar
  7. 7.
    Bleker OP, Reinders E. Bartholinitis en SOA. SOA Bull 1989;2:10–1.Google Scholar
  8. 8.
    Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:179–83.CrossRefPubMedGoogle Scholar
  9. 9.
    Thomason JL, Gelbart SM, James JA, Broekhuizenv FF. Vaginitis in reproductive-age women. Curr Opin Obstet Gynecol 1989;1:35–41.PubMedGoogle Scholar
  10. 10.
    Eschenbach DA, Hilier S, Critchlow C, Stevens MA, DeRouen T, Holmes KK. Diagnosis and clinical manifestations of bacterial vaginosis. Am J Obstet Gynecol 1988;158:819–28.PubMedGoogle Scholar
  11. 11.
    Van der Meijden WI, Duivenvoorden HJ, Both-Patoir HC, Hazen-Engelsman ME, Drogendijk AC. Clinical and laboratory findings in woman with bacterial vaginosis and trichomoniasis versus controls. Eur J Obstet cGynecol Reprod Biol 1988;28:39–52.CrossRefGoogle Scholar
  12. 12.
    Bump RC, Buesching WJ III. Bacterial vaginosis in virginal and sexually active adolescent females: evidence against sexal transmission. Am J Obstet Gynecol 1988;158:935–8.PubMedGoogle Scholar
  13. 13.
    Greaves W, Chungafung J, Morris B, Haile A, Thownsend JL. Clindamycin versus metronidazole in the treatment of bacterial vaginosis. Obstet Gynecol 1988;72:799–802.PubMedGoogle Scholar
  14. 14.
    Marchi B, Mugnaini F, Toscane L, De Lalla F. Treatment ofGardnerella vaginalis syndrome with new quinolones. Preliminary results. Rev Infect Dis 1989;11:S1308.Google Scholar
  15. 15.
    Bisschop MPJM. Vaginal candidosis [Dissertation]. Amsterdam: Free University, 1984.Google Scholar
  16. 16.
    Martinek G. Summary of clinical studies with vaginal formulation of terconazole. Gynak Rundschau 1985;25(Suppl 1):105–13.Google Scholar
  17. 17.
    Davey PG. New antiviral and antifungal drugs. Br Med J 1990;300:793–8.Google Scholar
  18. 18.
    Baldson MJ, Tobin JM. Vaginal candidosis: a prospective study of effectiveness of maintenance miconazol treatment. Genitourin Med 1988;64:124–7.PubMedGoogle Scholar
  19. 19.
    Soll DR. High frequency switching inCandida albicans and its relation to vaginal candidiasis. Am J Obstet Gynecol 1988;158:997–1001.PubMedGoogle Scholar
  20. 20.
    Lossick JG. The diagnosis of vaginal trichomoniasis. JAMA 1988;259:1230–5.CrossRefPubMedGoogle Scholar
  21. 21.
    Rein MF, Müller M.Trichomonas vaginalis. In: Holmes KK, Mardh PA, Sparling PF, Wiesner PJ, eds. Sexually transmitted diseases. New York: McGraw-Hill, 1984:525–36.Google Scholar
  22. 22.
    Valenti WM, Reese RE. Genitourinary infections. In: Reese RE, Gordon Douglas Jr. R, eds. A practical approach to infectious diseases. 2nd ed. Boston: Little, Brown and Company, 1986:327–58.Google Scholar
  23. 23.
    Ledger WJ. Current problems in antibiotic treatment in obstetrics and gynecology. Rev Infect Dis 1985;7, S4:679–89.Google Scholar
  24. 24.
    Westrom L. Pelvic inflammatory disease and other sexual transmitted diseases. Curr Opin Obstet Gynecol 1989;1:5–10.PubMedGoogle Scholar
  25. 25.
    Pearce MJ. Pelvic inflammatory disease. Br Med J 1990;300:1090–1.Google Scholar
  26. 26.
    Ridgik JH, Pock N. Pelvic inflammatory disease. Clinical update. J Am Osteop Assoc 1987;87(2):142–6.Google Scholar
  27. 27.
    Hager WD, Eschenbach DA, Spence MR, Sweet RL. Criteria for diagnosing and grading of salpingitis. Obstet Gynecol 1983;61:113–4.PubMedGoogle Scholar
  28. 28.
    Dodson MG. Optimum therapy for acute pelvic inflammatory disease. Drugs 1990;39:511–22.PubMedGoogle Scholar
  29. 29.
    Crombleholme WR, Schachter J, Sweet RL. Ciprofloxacin vs. clindamycin plus gentamycin in the treatment of acute pelvic inflammatory disease. Rev Infect Dis 1989;11:S1312–3.Google Scholar
  30. 30.
    Landers DV, Sweet RL. Tubo-ovarian abscess: contemporary approach to management. Rev Infect Dis 1983;5:876–84.PubMedGoogle Scholar
  31. 31.
    Gerzof SG, Robbins AH, Johnson WC, Birkett DH, Nabseth DC. Percutaneous catheter drainage of abdominal abscesses: a five year experience. N Engl J Med 1981;305:653–7.PubMedGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • Alphonse J. M. Roex
    • 1
  1. 1.Medical Centre AlkmaarAM Alkmaarthe Netherlands

Personalised recommendations