Association betweenStaphylococcus aureus nasopharyngeal colonization and septicemia in patients infected with the human immunodeficiency virus
In an attempt to identify risk factors forStaphylococcus aureus septicemia, 136 consecutive HIV-infected patients were investigated for the presence of nasopharyngeal colonization withStaphylococcus aureus and subsequentStaphylococcus aureus infection. Sixty of 136 (44.1 %) HIV-infected patients had staphylococci which were detected in the nasopharynx on initial culture compared to 12 of 39 (30.8 %) patients with chronic diseases and 11 of 47 (23.4 %) healthy hospital staff. Another 12 HIV-infected subjects proved to beStaphylococcus aureus carriers on follow-up cultures. Patients with full-blown AIDS had a higher carriage rate compared to subjects who were only HIV-positive (p<0.05), indicating thatStaphylococcus aureus colonized patients were more severely ill. Eight patients withStaphylococcus aureus septicemia were observed, all of whom were carriers; no septicemia occurred in the non-colonized patients (p<0.01). Colonized patients with neutropenia (< 1000/µl) were significantly more likely to develop septicemia (p<0.01). Nasopharyngeal colonization withStaphylococcus aureus and the presence of an indwelling catheter were established to be factors that help identify patients at risk of acquiring subsequentStaphylococcus aureus infection.
Unable to display preview. Download preview PDF.
- 18.Boelaert JR, DeSmedt RA, DeBaere YA, Godard CA, Matthys EG, Schurgers ML, Daneels RF, Gordts BZ, VanLanduyt HW The influence of calcium mupirocin nasal ointment on the incidence ofStaphylococcus aureus infections in haemodialysis patients. Nephrology, Dialysis, Transplantation 1989, 4: 278–281.Google Scholar