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Pharmaceutisch Weekblad

, Volume 9, Issue 3, pp 179–182 | Cite as

Kinetics of rate controlled rectally administered ranitidine to male volunteers

  • H. de Bree
  • A. C. de Boer
Short Communications

Abstract

Ranitidine hydrochloride solution was given rectally to six healthy volunteers by means of an osmotic pump (Osmet®) at a zero-order rate for 8 h. Quite constant steady-state drug concentrations were achieved in the range of 64–123 ng/ml plasma (meanCss: 100.6 ng/ml). The mean absorption time was 0.45 h (range 0–1.02 h), indicating that absorption was not always instantaneous. It is concluded that the Osmet® system together with the rectal route offer the possibility for achieving steady-state concentrations of ranitidine, enabling the determination of pharmacodynamic effects. In addition, the rectal route can be considered as an alternative to oral and intravenous administration.

Key words

Administration, rectal Osmotic pump Pharmacokinetics Ranitidine 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1987

Authors and Affiliations

  • H. de Bree
    • 1
  • A. C. de Boer
    • 1
  1. 1.Division of Pharmacology, Center for Bio-Pharmaceutical SciencesState University of LeidenRA LeidenThe Netherlands

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