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Fungicidal activity of cilofungin (LY121019) alone and in combination with anticapsin or other antifungal agents

  • M. Pfaller
  • R. Gordee
  • T. Gerarden
  • M. Yu
  • R. Wenzel
New Antimicrobial Agents

Abstract

Cilofungin (LY121019) was shown to have potent fungicidal activity against clinical isolates ofCandida albicans andCandida tropicalis but notCandida parapsilosis. Fungicidal activity was evident against both replicating and non-replicatingCandida albicans and was progressive over the first 12 h of incubation. The combination of cilofungin (LY121019) with anticapsin but not with amphotericin B, ketoconazole or 5-fluorocytosine resulted in synergistic fungicidal activity. This compound warrants further investigation of its safety and efficacy in the treatment ofCandida infections.

Keywords

Internal Medicine Amphotericin Clinical Isolate Ketoconazole Antifungal Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1989

Authors and Affiliations

  • M. Pfaller
    • 1
    • 2
  • R. Gordee
    • 4
  • T. Gerarden
    • 2
  • M. Yu
    • 2
  • R. Wenzel
    • 3
  1. 1.Veterans Administration Medical CenterIowa CityUSA
  2. 2.Department of PathologyUniversity of Iowa College of MedicineIowa CityUSA
  3. 3.Department of Internal MedicineUniversity of Iowa College of MedicineIowa CityUSA
  4. 4.Lilly Research LaboratoriesEli Lilly and CompanyIndianapolisUSA

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